(Q49122241)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21707925%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat (English)

1 reference

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6 February 2020

1 reference

8

1 reference

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6 February 2020

author name string

Aaro J Jalkanen

1

1 reference

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6 February 2020

Jenni J Hakkarainen

2

1 reference

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6 February 2020

Marko Lehtonen

3

1 reference

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6 February 2020

Tetta Venäläinen

4

1 reference

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6 February 2020

Tiina M Kääriäinen

5

1 reference

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6 February 2020

Elina Jarho

6

1 reference

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6 February 2020

Marjukka Suhonen

7

1 reference

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6 February 2020

publication date

28 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21707925%20AND%20SRC:MED&resulttype=core&format=json

Basic and Clinical Pharmacology and Toxicology

6 February 2020

published in

1 reference

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6 February 2020

volume

109

1 reference

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6 February 2020

issue

6

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6 February 2020

page(s)

443-451

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Proline specific peptidases

6 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Distribution of peptidase activity in teleost and rat tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Distribution of immunoreactive prolyl oligopeptidase in human and rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Distribution of prolyl endopeptidase activities in rat and human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Evolutionary relationships of the prolyl oligopeptidase family enzymes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein

21 January 2018

1 reference

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GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity

21 January 2018

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A common mechanism of action for three mood-stabilizing drugs

21 January 2018

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A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation

21 January 2018

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Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.

21 January 2018

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Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion

21 January 2018

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Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion.

21 January 2018

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Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders.

21 January 2018

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A prolyl oligopeptidase inhibitor, Z-Pro-Prolinal, inhibits glyceraldehyde-3-phosphate dehydrogenase translocation and production of reactive oxygen species in CV1-P cells exposed to 6-hydroxydopamine.

21 January 2018

1 reference

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Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and central cholinergic neurons in aged rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis

21 January 2018

1 reference

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A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease

21 January 2018

1 reference

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Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.

21 January 2018

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Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

21 January 2018

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Different effects of scopolamine and inhibition of prolyl oligopeptidase on mnemonic and motility functions of young and 8- to 9-month-old rats in the radial-arm maze

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Comparison of in vitro cell models in predicting in vivo brain entry of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-7843.2011.00747.X

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.

21 January 2018

1 reference

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Microdialysis--theory and application

21 January 2018

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The blood-brain barrier: bottleneck in brain drug development

21 January 2018

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Medicinal chemical properties of successful central nervous system drugs

21 January 2018

1 reference

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