(Q49243022)

19 February 2018

title

Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output. (English)

1 reference

19 February 2018

KRAS proto-oncogene, GTPase

main subject

KRAS

0 references

0 references

lipid sorting

0 references

author name string

Yong Zhou

1

1 reference

19 February 2018

Priyanka Prakash

2

1 reference

19 February 2018

Hong Liang

3

1 reference

19 February 2018

Kwang-Jin Cho

4

1 reference

19 February 2018

Alemayehu A Gorfe

5

1 reference

19 February 2018

John F Hancock

6

1 reference

19 February 2018

language of work or name

English

0 references

publication date

29 December 2016

1 reference

19 February 2018

published in

Cell

1 reference

19 February 2018

volume

168

1 reference

19 February 2018

issue

1-2

1 reference

19 February 2018

page(s)

239-251.e16

1 reference

19 February 2018

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.

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Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane.

22 May 2018

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22 May 2018

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SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

22 May 2018

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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

22 May 2018

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22 May 2018

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Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol.

22 May 2018

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22 May 2018

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Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters

22 May 2018

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22 May 2018

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Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission

22 May 2018

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N-Ras forms dimers at POPC membranes

22 May 2018

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Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis.

22 May 2018

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A comprehensive survey of Ras mutations in cancer

22 May 2018

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Revealing conformational substates of lipidated N-Ras protein by pressure modulation

22 May 2018

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Mechanism of membrane curvature sensing by amphipathic helix containing proteins

22 May 2018

1 reference

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Segregation of negatively charged phospholipids by the polycationic and farnesylated membrane anchor of Kras

22 May 2018

1 reference

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Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

22 May 2018

1 reference

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Signalling ballet in space and time

22 May 2018

1 reference

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Ras membrane orientation and nanodomain localization generate isoform diversity

22 May 2018

1 reference

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Electrostatic interactions positively regulate K-Ras nanocluster formation and function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

A novel switch region regulates H-ras membrane orientation and signal output

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Membrane phosphatidylserine regulates surface charge and protein localization

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

H-ras protein in a bilayer: interaction and structure perturbation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

22 May 2018

1 reference

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Scalable molecular dynamics with NAMD

22 May 2018

1 reference

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Single-molecule imaging analysis of Ras activation in living cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Location of the Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Effector Domain in Negatively Charged Phospholipid Bicelles

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Ras proteins: different signals from different locations

22 May 2018

1 reference

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Observing cell surface signaling domains using electron microscopy

22 May 2018

1 reference

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Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Escaping free-energy minima

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

PIP(2) and proteins: interactions, organization, and information flow

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

VMD: visual molecular dynamics

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

All ras proteins are polyisoprenylated but only some are palmitoylated

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Exhaustively sampling peptide adsorption with metadynamics.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653213

Trifluoperazine causes a disturbance in glycerophospholipid monolayers containing phosphatidylserine (PS): effects of pH, acyl unsaturation, and proportion of PS

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28041850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2016.11.059

1 reference

19 February 2018

PMCID

5653213

1 reference

19 February 2018

PubMed ID

28041850

1 reference

19 February 2018