(Q50042606)

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Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection.

scientific article published on 10 May 2011

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27 January 2020

Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection (English)

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27 January 2020

Salmonella Typhimurium

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Adriana Flores-Langarica

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27 January 2020

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27 January 2020

Denisse L Leyton

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27 January 2020

Jennifer L Marshall

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27 January 2020

Cristina Gil-Cruz

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27 January 2020

Constatino III Roberto López Macías

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27 January 2020

Constatino III Roberto López Macías

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27 January 2020

Ian R Henderson

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27 January 2020

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27 January 2020

Robert A Kingsley

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27 January 2020

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27 January 2020

Jessica Hitchcock

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27 January 2020

Margaret Goodall

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27 January 2020

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Shirdi E Letran

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27 January 2020

Fabrina Gaspal

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27 January 2020

Rebecca Chester

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27 January 2020

Jayne L Chamberlain

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27 January 2020

James Alexander

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27 January 2020

Ian C M MacLennan

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27 January 2020

Adam F Cunningham

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27 January 2020

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10 May 2011

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27 January 2020

European Journal of Immunology

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27 January 2020

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27 January 2020

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27 January 2020

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27 January 2020

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Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection.

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Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium

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A chromosomal region surrounding the ompD porin gene marks a genetic difference between Salmonella typhi and the majority of Salmonella serovars

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

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21 January 2018

Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses

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21 January 2018

Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1.

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Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response

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Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo.

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Induction of adaptive immunity by flagellin does not require robust activation of innate immunity

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Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin

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21 January 2018

CD4+-T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliC

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21 January 2018

Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium

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Segment IV of a Salmonella flagellin gene specifies flagellar antigen epitopes

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Salmonella typhimurium coordinately regulates FliC location and reduces dendritic cell activation and antigen presentation to CD4+ T cells

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Adoptive transfer of immunity to oral challenge with virulent salmonellae in innately susceptible BALB/c mice requires both immune serum and T cells

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Method for the isolation of highly purified Salmonella flagellins

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