Wikidata

(Q5005943)

English

Jun proto-oncogene, AP-1 transcription factor subunit

mammalian protein found in Homo sapiens

  • JUN
  • p39
  • Jun activation domain binding protein
  • enhancer-binding protein AP1
  • v-jun sarcoma virus 17 oncogene homolog
  • transcription factor AP-1
  • activator protein 1
  • jun oncogene
  • AP1
  • proto-oncogene cJun
  • proto-oncogene c-Jun
  • v-jun avian sarcoma virus 17 oncogene homolog
  • Proto-Oncogene Proteins c-jun
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
37 references
retrieved
8 April 2019
stated in
The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
TAF7 (TAFII55) plays a role in the transcription activation by c-Jun
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
UNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tyrosine kinase Syk regulates TPL2 activation signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
retrieved
8 April 2019
stated in
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IPI
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IBA
IC
IDA
ISA
ISM
NAS
7 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
ISA
retrieved
8 April 2019
stated in
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
cJun modulates Ggamma-globin gene expression via an upstream cAMP response element
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IBA
cell component
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IC
IDA
IEA
5 references
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
determination method or standard
IEA
retrieved
17 October 2017
stated in
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
17 October 2017
stated in
Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
17 October 2017
stated in
Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
17 October 2017
stated in
cJun modulates Ggamma-globin gene expression via an upstream cAMP response element
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412
determination method or standard
IC
positive regulation of transcription, DNA-templated
determination method or standard
IDA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IEA
retrieved
8 April 2019
stated in
The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IEA
retrieved
8 April 2019
stated in
Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro
GOA
curator
UniProt
UniProt protein ID
P05412
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
cJun modulates Ggamma-globin gene expression via an upstream cAMP response element
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412
determination method or standard
IBA
Gene Atlas image
PBB GE JUN 201464 x at fs.png
732 × 530; 12 KB
0 references
Commons category
Transcription factor Jun
0 references

Identifiers

MeSH descriptor ID
D016755
subject named as
Proto-Oncogene Proteins c-jun
0 references
Freebase ID
/m/02py1gd
0 references
 
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