(Q24302117)

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Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway

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scholarly article

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Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway (English)

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Disabled 2, mitogen-responsive phosphoprotein

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GOA release 2020-03-11

author name string

Barbara A Hocevar

1

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Celine Prunier

2

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Philip H Howe

3

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language of work or name

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publication date

8 July 2005

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Journal of Biological Chemistry

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280

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27

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25920-7

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JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspective

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JNK signaling pathway is required for efficient wound healing in Drosophila

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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New insights into TGF-beta-Smad signalling

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A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta

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Signal transduction by the JNK group of MAP kinases

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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The role of the Drosophila TAK homologue dTAK during development.

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Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

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Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2

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Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

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A transcriptional partner for MAD proteins in TGF-beta signalling

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

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Smad3/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner

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Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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Smads bind directly to the Jun family of AP-1 transcription factors

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Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

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Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

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TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

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Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

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Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction

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ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

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Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

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Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

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Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

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Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing.

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Crystal structures of the Dab homology domains of mouse disabled 1 and 2

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Wnt activates the Tak1/Nemo-like kinase pathway

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Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

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Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

1 reference

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Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

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Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen

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1 reference

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1 reference

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Fibronectin at a glance

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10.1074/JBC.M501150200

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