(Q50073487)

24 February 2018

title

The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors. (English)

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24 February 2018

author

Peter I Mackenzie

series ordinal

1

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24 February 2018

author name string

Dong Gui Hu

series ordinal

2

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24 February 2018

Dione A Gardner-Stephen

series ordinal

3

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24 February 2018

language of work or name

English

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publication date

1 February 2010

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24 February 2018

published in

Drug Metabolism Reviews

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24 February 2018

volume

42

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24 February 2018

page(s)

99-109

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24 February 2018

issue

1

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24 February 2018

Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate

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Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme

21 January 2018

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Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha

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FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

21 January 2018

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The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene

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UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects

21 January 2018

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The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7.

21 January 2018

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UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells

21 January 2018

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Isoform-specific regulation of uridine diphosphate-glucuronosyltransferase 2B enzymes in the human prostate: differential consequences for androgen and bioactive lipid inactivation

21 January 2018

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Regulation of the rat UGT1A6 by glucocorticoids involves a cryptic glucocorticoid response element

21 January 2018

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Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

21 January 2018

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Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1alpha.

21 January 2018

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Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expression

21 January 2018

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Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers

21 January 2018

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Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region

21 January 2018

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21 January 2018

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Tissue specific differences in the regulation of the UDP glucuronosyltransferase 2B17 gene promoter.

21 January 2018

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Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2.

21 January 2018

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Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.

21 January 2018

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Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview.

21 January 2018

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HNF1 alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter

21 January 2018

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Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone.

21 January 2018

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Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells

21 January 2018

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Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells

21 January 2018

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

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The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases

21 January 2018

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Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells

21 January 2018

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Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

21 January 2018

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Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

PXR and LXR in hepatic steatosis: a new dog and an old dog with new tricks

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

Gene expression of 17beta-estradiol-metabolizing isozymes: comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

Regulation of UDP glucuronosyltransferase genes.

21 January 2018

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Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases.

21 January 2018

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HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3

21 January 2018

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Tissue-specific 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible expression of human UDP-glucuronosyltransferase UGT1A6.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602530903209544

Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Control of pancreas and liver gene expression by HNF transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting P

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

CAR and PXR: the xenobiotic-sensing receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903209544

10.3109/03602530903209544

21 January 2018

Identifiers

DOI

1 reference

24 February 2018

PubMed ID

20070244

1 reference

24 February 2018