(Q50075745)

24 February 2018

title

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit. (English)

1 reference

24 February 2018

author name string

Daniel A Ritt

1

1 reference

24 February 2018

María T Abreu-Blanco

2

1 reference

24 February 2018

Lakshman Bindu

3

1 reference

24 February 2018

David E Durrant

4

1 reference

24 February 2018

Ming Zhou

5

1 reference

24 February 2018

Suzanne I Specht

6

1 reference

24 February 2018

Andrew G Stephen

7

1 reference

24 February 2018

Matthew Holderfield

8

1 reference

24 February 2018

Deborah K Morrison

9

1 reference

24 February 2018

publication date

15 November 2016

1 reference

24 February 2018

published in

Molecular Cell

1 reference

24 February 2018

volume

64

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24 February 2018

issue

5

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24 February 2018

page(s)

875-887

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24 February 2018

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

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Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis

22 May 2018

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22 May 2018

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BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

22 May 2018

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Regulation of RAF protein kinases in ERK signalling

22 May 2018

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Rigosertib induces cell death of a myelodysplastic syndrome-derived cell line by DNA damage-induced G2/M arrest

22 May 2018

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Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome

22 May 2018

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22 May 2018

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Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na

22 May 2018

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Tumor adaptation and resistance to RAF inhibitors

22 May 2018

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Allosteric activation of functionally asymmetric RAF kinase dimers

22 May 2018

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The importance of Raf dimerization in cell signaling

22 May 2018

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Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling

22 May 2018

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ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress

22 May 2018

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A MEK-independent role for CRAF in mitosis and tumor progression.

22 May 2018

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Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity

22 May 2018

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

22 May 2018

1 reference

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Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells.

22 May 2018

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Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

22 May 2018

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Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells

22 May 2018

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22 May 2018

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

22 May 2018

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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

22 May 2018

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

22 May 2018

1 reference

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Regulation of Raf-1 by direct feedback phosphorylation.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135640

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

22 May 2018

1 reference

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Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135640

Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.

22 May 2018

1 reference

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Signal transduction by tumor necrosis factor mediated by JNK protein kinases

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135640

Taxol (paclitaxel): mechanisms of action

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135640

MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5135640

The JNK signal transduction pathway

22 May 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27889448

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2016.10.029

1 reference

24 February 2018

PMC publication ID

5135640

1 reference

24 February 2018

PubMed publication ID

27889448

1 reference

24 February 2018