(Q50113187)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29317493%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

title

Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism (English)

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8 April 2020

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3

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8 April 2020

William P Katt

9

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8 April 2020

author name string

Qingqiu Huang

1

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8 April 2020

Clint Stalnecker

2

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8 April 2020

Lee A McDermott

4

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8 April 2020

Prema Iyer

5

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8 April 2020

Jason O'Neill

6

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8 April 2020

Shawn Reimer

7

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8 April 2020

Richard A Cerione

8

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8 April 2020

language of work or name

English

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publication date

9 January 2018

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Journal of Biological Chemistry

8 April 2020

published in

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8 April 2020

volume

293

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8 April 2020

issue

10

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8 April 2020

page(s)

3535-3545

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Biosynthesis and processing of renal mitochondrial glutaminase in cultured proximal tubular epithelial cells and in isolated mitochondria.

8 April 2020

cites work

1 reference

12 December 2020

Properties of rat renal phosphate-dependent glutaminase coupled to Sepharose. Evidence that dimerization is essential for activation

1 reference

12 December 2020

Designed replacement of an internal hydration water molecule in BPTI: structural and functional implications of a glycine-to-serine mutation.

1 reference

12 December 2020

In vitro characterization of the mitochondrial processing and the potential function of the 68-kDa subunit of renal glutaminase

1 reference

12 December 2020

Role of the N-terminal 118 amino acids in the processing of the rat renal mitochondrial glutaminase precursor

1 reference

12 December 2020

Isolation, characterization and expression of a human brain mitochondrial glutaminase cDNA

1 reference

12 December 2020

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

1 reference

12 December 2020

Coot: model-building tools for molecular graphics

1 reference

12 December 2020

Angiogenesis as a therapeutic target

1 reference

12 December 2020

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

1 reference

12 December 2020

VEGF-targeted therapy: mechanisms of anti-tumour activity.

1 reference

12 December 2020

Phasercrystallographic software

1 reference

12 December 2020

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

1 reference

12 December 2020

The Warburg effect and mitochondrial stability in cancer cells

1 reference

12 December 2020

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism

1 reference

12 December 2020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

12 December 2020

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

1 reference

12 December 2020

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

1 reference

12 December 2020

Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS.

1 reference

12 December 2020

Glutaminase: a hot spot for regulation of cancer cell metabolism?

1 reference

12 December 2020

Regulation of cancer cell metabolism

1 reference

12 December 2020

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

1 reference

12 December 2020

Full-length human glutaminase in complex with an allosteric inhibitor

1 reference

12 December 2020

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

1 reference

12 December 2020

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

1 reference

12 December 2020

Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation.

1 reference

12 December 2020

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

1 reference

12 December 2020

Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth

1 reference

12 December 2020

Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer.

1 reference

12 December 2020

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

1 reference

12 December 2020

Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor

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12 December 2020

Therapeutic strategies impacting cancer cell glutamine metabolism

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12 December 2020

Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

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12 December 2020

Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention

1 reference

12 December 2020

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

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12 December 2020

Reduction of lattice disorder in protein crystals by high-pressure cryocooling.

1 reference

12 December 2020

Design and evaluation of novel glutaminase inhibitors

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12 December 2020

The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.

1 reference

12 December 2020

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase

1 reference

12 December 2020

Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.

1 reference

12 December 2020

A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis.

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M117.810101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29317493%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

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8 April 2020

PubMed publication ID

29317493

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