(Q50278958)

28 February 2018

title

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability. (English)

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28 February 2018

main subject

Caenorhabditis elegans

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Peter Zeller

1

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Susan M. Gasser

object named as

Susan M Gasser

6

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Marcel Tijsterman

object named as

Marcel Tijsterman

5

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author name string

Jan Padeken

2

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28 February 2018

Robin van Schendel

3

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28 February 2018

Veronique Kalck

4

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28 February 2018

language of work or name

English

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publication date

26 September 2016

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28 February 2018

published in

Nature Genetics

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28 February 2018

volume

48

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28 February 2018

issue

11

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28 February 2018

page(s)

1385-1395

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28 February 2018

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

cites work

1 reference

7 January 2021

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome

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Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

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De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

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Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

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H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

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The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis.

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The distribution of repressive histone modifications on silenced FMR1 alleles provides clues to the mechanism of gene silencing in fragile X syndrome

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Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease

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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

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A combined chemical and genetic approach for the generation of induced pluripotent stem cells

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Repetitive DNA and next-generation sequencing: computational challenges and solutions

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Histone H3-K9 methyltransferase ESET is essential for early development

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Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

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7 January 2021

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.

1 reference

7 January 2021

H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability

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7 January 2021

Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development

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7 January 2021

Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.

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7 January 2021

Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants

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7 January 2021

Requirement of heterochromatin for cohesion at centromeres

1 reference

7 January 2021

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans

1 reference

7 January 2021

Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

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7 January 2021

Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi

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7 January 2021

CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans

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7 January 2021

Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

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7 January 2021

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

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7 January 2021

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

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7 January 2021

Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project

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7 January 2021

Broad chromosomal domains of histone modification patterns in C. elegans

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7 January 2021

Repetitive DNA sequences located in the terminal portion of the Caenorhabditis elegans chromosomes

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7 January 2021

Repeat DNA in genome organization and stability.

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7 January 2021

Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline

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7 January 2021

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

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7 January 2021

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7 January 2021

Causes of genome instability

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7 January 2021

Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae

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7 January 2021

DNA replication fork pause sites dependent on transcription

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7 January 2021

Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription

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7 January 2021

Co-directional replication-transcription conflicts lead to replication restart

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7 January 2021

RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability

1 reference

7 January 2021

Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.

1 reference

7 January 2021

Mobile elements and the human genome

1 reference

7 January 2021

Characterization of monoclonal antibody to DNA.RNA and its application to immunodetection of hybrids

1 reference

7 January 2021

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development

1 reference

7 January 2021

R loops are linked to histone H3 S10 phosphorylation and chromatin condensation

1 reference

7 January 2021

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

1 reference

7 January 2021

S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.

1 reference

7 January 2021

HYDROXYUREA: A SPECIFIC INHIBITOR OF DEOXYRIBONUCLEIC ACID SYNTHESIS

1 reference

7 January 2021

R-loop-mediated genomic instability is caused by impairment of replication fork progression

1 reference

7 January 2021

An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae

1 reference

7 January 2021

Activation of a transposable element in the germ line but not the soma of Caenorhabditis elegans.

1 reference

7 January 2021

Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi

1 reference

7 January 2021

Repetitive Transgenes in C. elegans Accumulate Heterochromatic Marks and Are Sequestered at the Nuclear Envelope in a Copy-Number- and Lamin-Dependent Manner

1 reference

7 January 2021

New lysine methyltransferase drug targets in cancer

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7 January 2021

Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

1 reference

7 January 2021

Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans.

1 reference

7 January 2021

Mechanisms of genome instability induced by RNA-processing defects

1 reference

7 January 2021

Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria

1 reference

7 January 2021

The regulation and functions of the nuclear RNA exosome complex.

1 reference

7 January 2021

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

1 reference

7 January 2021

Transcription as a source of genome instability

1 reference

7 January 2021

DNA topology and transcription

1 reference

7 January 2021

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.

1 reference

7 January 2021

Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells

1 reference

7 January 2021

The spatial dynamics of tissue-specific promoters during C. elegans development

1 reference

7 January 2021

The organization of histone H3 modifications as revealed by a panel of specific monoclonal antibodies

1 reference

7 January 2021

Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2

1 reference

7 January 2021

QuasR: quantification and annotation of short reads in R.

1 reference

7 January 2021

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

1 reference

7 January 2021

Repbase Update, a database of eukaryotic repetitive elements

1 reference

7 January 2021

Fast and accurate short read alignment with Burrows-Wheeler transform

1 reference

7 January 2021

The Sequence Alignment/Map format and SAMtools

1 reference

7 January 2021

Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads

1 reference

7 January 2021

Methods for studying the DNA damage response in the Caenorhabdatis elegans germ line

1 reference

7 January 2021

R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters

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7 January 2021

Identifiers

DOI

10.1038/NG.3672

1 reference

28 February 2018

1 reference

28 February 2018