(Q50298137)

English

CBL binds MET

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-8874685)

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Statements

biological process

1 reference

8 July 2022

Negative regulation of MET activity

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-8874685

1 reference

8 July 2022

CBL:GRB2,CBL [cytosol]

1

object has role

1 reference

8 July 2022

HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane]

1

object has role

1 reference

8 July 2022

HGF:p-4Y-MET dimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL) [plasma membrane]

1

object has role

1 reference

8 July 2022

c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination

1 reference

8 July 2022

Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

1 reference

8 July 2022

A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.

1 reference

8 July 2022

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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