(Q50336381)

5 March 2018

title

Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins. (English)

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5 March 2018

author name string

Daisuke Oikawa

1

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5 March 2018

Yukio Kimata

2

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5 March 2018

Kenji Kohno

3

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5 March 2018

Takao Iwawaki

4

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5 March 2018

language of work or name

English

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publication date

16 June 2009

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5 March 2018

Experimental Cell Research

published in

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5 March 2018

volume

315

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5 March 2018

issue

15

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5 March 2018

page(s)

2496-2504

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5 March 2018

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Tripartite management of unfolded proteins in the endoplasmic reticulum

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Bypassing a Kinase Activity with an ATP-Competitive Drug

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

How transmembrane proteins sense endoplasmic reticulum stress

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

7 January 2021

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Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain

7 January 2021

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Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha

7 January 2021

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The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response

7 January 2021

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On the mechanism of sensing unfolded protein in the endoplasmic reticulum

7 January 2021

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Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1

7 January 2021

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Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators.

7 January 2021

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An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1.

7 January 2021

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress

7 January 2021

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Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2009.06.009

Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation

7 January 2021

1 reference

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10.1016/J.YEXCR.2009.06.009

7 January 2021

Identifiers

DOI

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5 March 2018

PubMed ID

19538957

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5 March 2018