(Q50337127)

English

MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells.

scientific article published on 21 February 2007

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scholarly article

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

MADD/DENN splice variant of the IG20 gene is a negative regulator of caspase-8 activation. Knockdown enhances TRAIL-induced apoptosis of cancer cells. (English)

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

author name string

Nirupama Mulherkar

1

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

Kanteti V Prasad

2

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

Bellur S Prabhakar

3

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

language of work or name

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publication date

21 February 2007

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

Journal of Biological Chemistry

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

282

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

11715-11721

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

16

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

DENN, a novel human gene differentially expressed in normal and neoplastic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2- and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

LRDD, a novel leucine rich repeat and death domain containing protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

A unified model for apical caspase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Mechanisms of caspase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Insights into the regulatory mechanism for caspase-8 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M701085200

21 January 2018

Identifiers

10.1074/JBC.M701085200

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

1 reference

Europe PubMed Central

5 March 2018

http://europepmc.org/abstract/MED/17314102

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