(Q50479057)

14 March 2018

title

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy (English)

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14 March 2018

main subject

phase II clinical trial

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1

Eduardo Tolosa

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14 March 2018

5

Andrew Lees

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14 March 2018

2

Irene Litvan

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ORCID Public Data File 2021

14 March 2018

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author name string

Günter U Höglinger

3

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14 March 2018

David Burn

4

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María V Andrés

6

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14 March 2018

Belén Gómez-Carrillo

7

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14 March 2018

Teresa León

8

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Teodoro Del Ser

9

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14 March 2018

TAUROS Investigators

10

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14 March 2018

language of work or name

English

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publication date

14 February 2014

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14 March 2018

published in

Movement Disorders

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14 March 2018

volume

29

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14 March 2018

issue

4

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14 March 2018

page(s)

470-478

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14 March 2018

Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges

cites work

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Progressive supranuclear palsy: where are we now?

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CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

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GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.

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Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

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21 January 2018

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Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib

21 January 2018

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A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

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Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

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NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders

21 January 2018

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Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial.

21 January 2018

1 reference

Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop

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A new rating scale for age-related white matter changes applicable to MRI and CT.

21 January 2018

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A clinical rating scale for progressive supranuclear palsy

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The timed "Up & Go": a test of basic functional mobility for frail elderly persons

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Reliability, validity, and clinical correlates of apathy in Parkinson's disease

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EQ-5D: a measure of health status from the EuroQol Group

21 January 2018

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Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis

21 January 2018

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Donepezil in the treatment of progressive supranuclear palsy

21 January 2018

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Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, placebo-controlled trial

21 January 2018

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Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy

21 January 2018

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Idazoxan treatment in progressive supranuclear palsy

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.25824

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14 March 2018

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14 March 2018