(Q50521606)

14 March 2018

title

R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts. (English)

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14 March 2018

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Johanne Martel-Pelletier

4

Johanne Martel-Pelletier

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14 March 2018

Jean-Pierre Pelletier

5

Jean-Pierre Pelletier

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14 March 2018

6

Daniel Lajeunesse

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14 March 2018

Élie Abed

1

Élie Abed

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14 March 2018

Aline Delalandre

3

Aline Delalandre

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14 March 2018

author name string

Thomas F Chan

2

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14 March 2018

publication date

1 December 2011

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14 March 2018

published in

Arthritis & Rheumatology

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14 March 2018

volume

63

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14 March 2018

issue

12

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14 March 2018

page(s)

3865-3875

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14 March 2018

Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy

cites work

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Bone marrow lesions predict increase in knee cartilage defects and loss of cartilage volume in middle-aged women without knee pain over 2 years

21 January 2018

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Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis

21 January 2018

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Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

21 January 2018

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The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence

21 January 2018

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Bone Mass in Primary Coxarthrosis

21 January 2018

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Does a single local absorptiometric bone measurement indicate the overall skeletal status? Implications for osteoporosis and osteoarthritis of the hip.

21 January 2018

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Osteoarthritis: a problem of growth not decay?

21 January 2018

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Abnormal cancellous bone collagen metabolism in osteoarthritis

21 January 2018

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Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients

21 January 2018

1 reference

Toward a molecular understanding of skeletal development

21 January 2018

1 reference

WNT and beta-catenin signalling: diseases and therapies

21 January 2018

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Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity

21 January 2018

1 reference

The role of transforming growth factor-beta on retarded osteoblastic differentiation in vitro

21 January 2018

1 reference

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

21 January 2018

1 reference

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

21 January 2018

1 reference

R-Spondin proteins: a novel link to beta-catenin activation

21 January 2018

1 reference

Dynamic expression of R-spondin family genes in mouse development.

21 January 2018

1 reference

Craniofacial malformation in R-spondin2 knockout mice.

21 January 2018

1 reference

R-Spondin family members regulate the Wnt pathway by a common mechanism

21 January 2018

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R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression

21 January 2018

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Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2

21 January 2018

1 reference

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

21 January 2018

1 reference

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis

21 January 2018

1 reference

Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition

21 January 2018

1 reference

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

21 January 2018

1 reference

Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts

21 January 2018

1 reference

Measurement of protein using bicinchoninic acid

21 January 2018

1 reference

An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction

21 January 2018

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Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts

21 January 2018

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BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression

21 January 2018

1 reference

Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism

21 January 2018

1 reference

Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling

21 January 2018

1 reference

Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts

21 January 2018

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Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression

21 January 2018

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BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.

21 January 2018

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Function and biological roles of the Dickkopf family of Wnt modulators

21 January 2018

1 reference

Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

21 January 2018

1 reference

F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.

21 January 2018

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Composition and Mechanical Properties of Cancellous Bone from the Femoral Head of Patients with Osteoporosis or Osteoarthritis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.30625

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14 March 2018

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14 March 2018