(Q50542693)

15 March 2018

title

High-throughput screening of excipients intended to prevent antigen aggregation at air-liquid interface. (English)

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15 March 2018

author name string

Sébastien Dasnoy

1

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15 March 2018

Nancy Dezutter

2

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15 March 2018

Dominique Lemoine

3

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15 March 2018

Vivien Le Bras

4

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15 March 2018

Véronique Préat

5

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15 March 2018

publication date

12 March 2011

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15 March 2018

published in

Pharmaceutical Research

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15 March 2018

volume

28

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15 March 2018

issue

7

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15 March 2018

page(s)

1591-1605

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15 March 2018

Current perspectives on stability of protein drug products during formulation, fill and finish operations

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1 reference

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Structure-immunogenicity relationships of therapeutic proteins

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Methods for studying protein adsorption.

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Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces

21 January 2018

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Protein denaturation by combined effect of shear and air-liquid interface

21 January 2018

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Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation

21 January 2018

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Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin

21 January 2018

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Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution

21 January 2018

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Adsorption and function of recombinant Factor VIII at the air-water interface in the presence of Tween 80.

21 January 2018

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Formulation development of antibodies using robotic system and high-throughput laboratory (HTL).

21 January 2018

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A high throughput protein formulation platform: case study of salmon calcitonin

21 January 2018

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Application of extrinsic fluorescence spectroscopy for the high throughput formulation screening of aluminum-adjuvanted vaccines

21 January 2018

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A simple method for displaying the hydropathic character of a protein

21 January 2018

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Multichannel pipettor performance verified by measuring pathlength of reagent dispensed into a microplate

21 January 2018

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Evaluation of the information content in infrared spectra for protein secondary structure determination

21 January 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

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Nile red as a polarity-sensitive fluorescent probe of hydrophobic protein surfaces

21 January 2018

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Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red.

21 January 2018

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Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products

21 January 2018

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Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients.

21 January 2018

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The effects of substituted cyclodextrins on the colloidal and conformational stability of selected proteins

21 January 2018

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Techniques for assessing the effects of pharmaceutical excipients on the aggregation of porcine growth hormone

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Minimizing the Aggregation of Neutral Insulin Solutions

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12 December 2020

Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states

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12 December 2020

Prevention of Insulin Aggregation by Dicarboxylic Amino Acids During Prolonged Infusion

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Shaken, not stirred: mechanical stress testing of an IgG1 antibody

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12 December 2020

Induction and analysis of aggregates in a liquid IgG1-antibody formulation

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12 December 2020

Dual effects of Tween 80 on protein stability

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12 December 2020

Examination of the secondary structure of proteins by deconvolved FTIR spectra

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12 December 2020

Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII

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12 December 2020

Minimization of shaking-induced formation of insoluble aggregates of insulin by cyclodextrins

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12 December 2020

Protein secondary structures in water from second-derivative amide I infrared spectra

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12 December 2020

Effect of surfactants on the physical stability of recombinant human growth hormone

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12 December 2020

Use of poloxamer polymers to stabilize recombinant human growth hormone against various processing stresses

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12 December 2020

Aggregation of insulin and its prevention by carbohydrate excipients

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12 December 2020

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

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12 December 2020

AVAILABILITY OF DRUGS IN THE PRESENCE OF SURFACE-ACTIVE AGENTS. I. CRITICAL MICELLE CONCENTRATIONS OF SOME OXYETHYLENE OXYPROPYLENE POLYMERS

1 reference

12 December 2020

10.1007/S11095-011-0393-X

Identifiers

DOI

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15 March 2018

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15 March 2018