(Q5057534)

English

celastrol

chemical compound

3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Tripterine
(2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid
D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-

In more languages

Statements

type of chemical entity

0 references

carboxylic acid

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chemical structure

Celastrol.svg
512 × 414; 26 KB

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450.27701±0 dalton

1 reference

language of work or name

celastrol (English)

7 October 2016

stereoisomer of

(2R,4aR,6aS,6aR,14aR,14bS)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid

1 reference

based on heuristic

inferred from InChI

chemical formula

C₂₉H₃₈O₄

1 reference

language of work or name

celastrol (English)

7 October 2016

canonical SMILES

CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O

1 reference

language of work or name

celastrol (English)

7 October 2016

isomeric SMILES

CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O

1 reference

language of work or name

celastrol (English)

7 October 2016

2 references

Steroidal alkaloids

Taxonomy and chemotaxonomy of some species of celastraceae

Celastrus orbiculatus

2 references

Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production

Terpenoids from root bark of Celastrus orbiculatus

Tripterygium regelii

3 references

Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.

Triterpenoids from Tripterygium wilfordii

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

Salacia kraussii

1 reference

Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.

Celastrus paniculatus

1 reference

Quinone-methide, phenolic and related triterpenoids of plants of Celastraceae: further evidence for the structure ofCelastranhydride

Crossopetalum gaumeri

1 reference

Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri

Kokoona ochracea

1 reference

Quinone-methide triterpenes and salaspermic acid from Kokoona ochracea

Kokoona zeylanica

2 references

Studies on terpenoids and steroids. Part 10. Structures of four new natural phenol is D:A-friedo-24-noroleanane triterpenoids

Studies on terpenoids and steroids. Part 3. Structure and synthesis of a new phenolic D:A-friedo-24-noroleanane triterpenoid, zeylasterone, from kokoona zeylanica

Maytenus amazonica

1 reference

Structure of new bioactive triterpenes related to 22-β-hydroxy-tingenone

Maytenus woodsonii

1 reference

New Phenolic and Quinone-methide Triterpenes fromMaytenusSpecies (Celastraceae)

Maytenus chubutensis

1 reference

Triterpenoid and Phenolic Compounds from Two Chilean Celastraceae

Maytenus scutioides

2 references

Structure and absolute configuration of triterpene dimers from Maytenus scutioides

Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae)

Orthosphenia mexicana

2 references

Crystal structure of orthosphenic acid

Sesquiterpenes from Orthosphenia mexicana

Reissantia buchananii

2 references

Antitumor Agents 228. Five New Agarofurans, Reissantins A-E, and Cytotoxic Principles from Reissantia buchananii

Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.

Kothala himbutu

1 reference

Biogenetically important quinonemethides and other triterpenoid constituents of Salacia reticulata

Monteverdia krukovii

1 reference

Antimitotic quinoid triterpenes from Maytenus chuchuhuasca

Celastrus hypoleucus

2 references

A New Nortriterpene from the Root of Celastrus hypoleucus

Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus

Tricerma vitis-idaeum

1 reference

Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa

Hippocratea volubilis

1 reference

Friedelanes and triterpenoid quinone methides from Hippocratea excelsa

Maytenus canariensis

1 reference

Taxonomy and chemotaxonomy of some species of celastraceae

Monteverdia macrocarpa

1 reference

Antimitotic quinoid triterpenes from Maytenus chuchuhuasca

Tripterygium hypoglaucum

2 references

Di- and triterpenoids from Tripterygium hypoglaucum

Terpenoids from Tripterigyum hypoglaucum

Maytenus umbellata

1 reference

Taxonomy and chemotaxonomy of some species of celastraceae

Trichosanthes kirilowii

1 reference

An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB.

Maytenus spinosa

2 references

Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae)

Structure and absolute configuration of triterpene dimers from Maytenus scutioides

Tripterygium wilfordii

12 references

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

Terpenoids from Tripterigyum hypoglaucum

Triterpenoids from Tripterygium wilfordii

Di- and triterpenoids from Tripterygium hypoglaucum

Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.

Terpenoids in transformed root culture of Tripterygium wilfordii

D:A-friedo-24-noroleanane triterpenoids from Tripterigium wilfordii

A diterpenoid and triterpenes from tissue cultures of Tripterygium wilfordii

Terpenoids from Tripterygium wilfordii.

Triterpenoid inhibitors of interleukin-1 secretion and tumour-promotion from Tripterygium wilfordii var. regelii

Terpenoids from Tripterygium wilfordii

Gambogic acid, a natural product inhibitor of Hsp90

Monteverdia truncata

1 reference

Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography.

Monteverdia ilicifolia

1 reference

Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography.

Peritassa campestris

2 references

Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography.

Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris

Monteverdia spinosa

2 references

Structure and absolute configuration of triterpene dimers from Maytenus scutioides

Scutione, a new bioactive norquinonemethide triterpene from Maytenus scutioides (Celastraceae)

Commons category

Celastrol

0 references

Identifiers

InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1

1 reference

language of work or name

celastrol (English)

7 October 2016

KQJSQWZMSAGSHN-JJWQIEBTSA-N

2 references

language of work or name

celastrol (English)

7 October 2016

ChEBI release 2020-09-01

CAS Registry Number

2 references

language of work or name

celastrol (English)

7 October 2016

KQJSQWZMSAGSHN-JJWQIEBTSA-N

CAS Common Chemistry

10 April 2021

https://commonchemistry.cas.org/detail?cas_rn=34157-83-0

1 reference

language of work or name

Celastrol (English)

7 October 2016

1 reference

language of work or name

celastrol (English)

7 October 2016

Reaxys registry number

2194425

1 reference

language of work or name

celastrol (English)

7 October 2016

mapping relation type

1 reference

language of work or name

celastrol (English)

7 October 2016

1 reference

language of work or name

CELASTROL (English)

7 October 2016

UniChem compound ID

1 reference

splash10-0btc-0019500000-f16bbb2265231439975e

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splash10-05fr-0090500000-855c8d3ad1c355393f4c

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splash10-002u-0090200000-782324d0169fb1581155

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DSSTox substance ID

1 reference

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

DSSTOX compound identifier

0 references

636-472-5

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid (English)

CAS no.: 34157-83-0 (English)

ECHA Substance Infocard ID

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

27 December 2018

(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid (English)

CAS no.: 34157-83-0 (English)

Guide to Pharmacology Ligand ID

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

5 February 2021

Human Metabolome Database ID

1 reference

based on heuristic

inferred from InChIKey

1 reference

Global Substance Registration System

language of work or name

CELASTROL (English)

7 October 2016

Probes And Drugs ID

0 references

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Microsoft Academic ID

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1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Sitelinks

Wikipedia(7 entries)

cawiki Celastrol
enwiki Celastrol
eswiki Celastrol
frwiki Célastrol
shwiki Celastrol
srwiki Celastrol
ukwiki Целастрол

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Celastrol

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