(Q50590488)

16 March 2018

title

Molecular pathophysiology of psoriasis and molecular targets of antipsoriatic therapy. (English)

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16 March 2018

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2

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16 March 2018

author name string

Emoke Rácz

series ordinal

1

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16 March 2018

publication date

14 December 2009

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16 March 2018

Expert Reviews in Molecular Medicine

published in

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16 March 2018

volume

11

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16 March 2018

page(s)

e38

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16 March 2018

Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)

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Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin

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Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

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The Cytokine Network in Lesional and Lesion-Free Psoriatic Skin Is Characterized by a T-Helper Type 1 Cell-Mediated Response

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IL-22 increases the innate immunity of tissues

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Impaired Langerhans cell migration in psoriasis

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Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells

21 January 2018

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Dermal injection of immunocytes induces psoriasis

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Hormonal effect on psoriasis in pregnancy and post partum

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Efficacy and tolerability of biologic and nonbiologic systemic treatments for moderate-to-severe psoriasis: meta-analysis of randomized controlled trials

21 January 2018

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Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trial

21 January 2018

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

21 January 2018

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

21 January 2018

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New biologics for psoriasis and psoriatic arthritis.

21 January 2018

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Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha

21 January 2018

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Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis

21 January 2018

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TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

21 January 2018

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Tumor necrosis factor antagonist mechanisms of action: a comprehensive review

21 January 2018

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Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

21 January 2018

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A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

21 January 2018

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Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris

21 January 2018

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Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation.

21 January 2018

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The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis

21 January 2018

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Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy

21 January 2018

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Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2.

21 January 2018

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Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

21 January 2018

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Stat3 regulates genes common to both wound healing and cancer

21 January 2018

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Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

21 January 2018

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Lessons learned from psoriatic plaques concerning mechanisms of tissue repair, remodeling, and inflammation

21 January 2018

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Polymorphisms of the IL12B and IL23R genes are associated with psoriasis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Interleukin-1 in human skin: dysregulation in psoriasis

21 January 2018

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In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

21 January 2018

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Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

21 January 2018

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T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis

21 January 2018

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In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered

21 January 2018

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Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation

21 January 2018

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Laser treatment of psoriasis

21 January 2018

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Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

21 January 2018

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Evidence for vascular endothelial growth factor (VEGF) as a modifier gene in psoriasis

21 January 2018

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IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.

21 January 2018

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Angiogenesis and chronic inflammation: cause or consequence?

21 January 2018

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The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis.

21 January 2018

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

21 January 2018

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A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Genomic-scale analysis of psoriatic skin reveals differentially expressed insulin-like growth factor-binding protein-7 after phototherapy

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Novel insight into the agonistic mechanism of alefacept in vivo: differentially expressed genes may serve as biomarkers of response in psoriasis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Gene expression profiles in psoriasis: analysis of impact of body site location and clinical severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Type I interferon: potential therapeutic target for psoriasis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Increased expression of Wnt5a in psoriatic plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Psoriasis is associated with increased beta-defensin genomic copy number

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Innate immunity and antimicrobial defense systems in psoriasis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Psoriasis: dysregulation of innate immunity

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Innate and adaptive immunity and the pathophysiology of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Growth factor and proto-oncogene expression in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

CCL27-CCR10 interactions regulate T cell-mediated skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

The expression of p63 during epidermal remodeling in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Chemokines and other mediators as therapeutic targets in psoriasis vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Epidermal growth factor/transforming growth factor alpha receptors and psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Pathogenesis and therapy of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Variations in the genes encoding the peroxisome proliferator-activated receptors alpha and gamma in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Neovastat (AE-941), an inhibitor of angiogenesis: Randomized phase I/II clinical trial results in patients with plaque psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Micellar paclitaxel improves severe psoriasis in a prospective phase II pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Clinical and histologic evaluation of psoriatic plaques treated with a flashlamp pulsed dye laser

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Immunohistochemical evaluation of psoriatic plaques following selective photothermolysis of the superficial capillaries

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Epidermal HLA-DR and the enhancement of cutaneous reactivity to superantigenic toxins in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Superantigens. Do they have a role in skin diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Clearance of severe psoriasis after allogenic bone marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

The vast majority of CLA+ T cells are resident in normal skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Abnormal sequence of expression of differentiation markers in psoriatic epidermis: inversion of two steps in the differentiation program?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Delayed onset of epidermal differentiation in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

21 January 2018

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Antimicrobial peptides: an emerging concept in cutaneous biology

21 January 2018

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More than one way to skin . .

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Traditional systemic treatments have not fully met the needs of psoriasis patients: results from a national survey

21 January 2018

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https://api.crossref.org/works/10.1017%2FS146239940900129X

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Genomic Analysis Defines a Cancer-Specific Gene Expression Signature for Human Squamous Cell Carcinoma and Distinguishes Malignant Hyperproliferation from Benign Hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Type 17 T helper cells-origins, features and possible roles in rheumatic disease

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Interleukin-1: A key inflammatory mediator in psoriasis?

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https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling

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https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies

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https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

IL-1 beta and IFN-gamma induce the regenerative epidermal phenotype of psoriasis in the transwell skin organ culture system. IFN-gamma up-regulates the expression of keratin 17 and keratinocyte transglutaminase via endogenous IL-1 production

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Psoriasis after allogeneic bone marrow transplantation.

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Psoriasis induced by interferon-α

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Exacerbation of psoriasis by interferon-alpha therapy for hepatitis C

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Intraepidermal accumulation of polymorphonuclear leukocytes in chronic stable plaque psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

IL-20 gene expression is induced by IL-1beta through mitogen-activated protein kinase and NF-kappaB-dependent mechanisms

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Involvement of insulin-like growth factor-I in psoriasis as a paracrine growth factor: dermal fibroblasts play a regulatory role in developing psoriatic lesions

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Stratum corneum structure and function correlates with phenotype in psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Detailed genetic characterization of the interleukin-23 receptor in psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Identification of Cellular Pathways of "Type 1," Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

https://api.crossref.org/works/10.1017%2FS146239940900129X

1 reference

7 January 2021

Oligoclonal expansion of intraepidermal T cells in psoriasis skin lesions

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

https://api.crossref.org/works/10.1017%2FS146239940900129X

1 reference

7 January 2021

Variants in the 5q31 cytokine gene cluster are associated with psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

A subset of macrophages located along the basement membrane ("lining cells") is a characteristic histopathological feature of psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Cellular Genomic Maps Help Dissect Pathology in Human Skin Disease

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Effects of etanercept are distinct from infliximab in modulating proinflammatory genes in activated human leukocytes

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Etanercept induces apoptosis of dermal dendritic cells in psoriatic plaques of responding patients

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Psoriasis response to the pulsed dye laser

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https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Prominent Production of IL-20 by CD68+/CD11c+ Myeloid-Derived Cells in Psoriasis: Gene Regulation and Cellular Effects

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7 January 2021

https://api.crossref.org/works/10.1017%2FS146239940900129X

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7 January 2021

Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

Early inflammatory changes in the "perilesional skin" of psoriatic plaques: is there interaction between dendritic cells and keratinocytes?

1 reference

https://api.crossref.org/works/10.1017%2FS146239940900129X

7 January 2021

10.1017/S146239940900129X

Identifiers

DOI

1 reference

16 March 2018

1 reference

16 March 2018