(Q50876705)

24 March 2018

title

Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. (English)

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24 March 2018

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Jagan M R Pongubala

1

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24 March 2018

Daniel L Northrup

2

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24 March 2018

David W Lancki

3

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24 March 2018

Kay L Medina

4

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24 March 2018

Thomas Treiber

5

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24 March 2018

Eric Bertolino

6

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24 March 2018

Matthew Thomas

7

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24 March 2018

Rudolf Grosschedl

8

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24 March 2018

David Allman

9

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24 March 2018

Harinder Singh

10

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24 March 2018

language of work or name

English

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publication date

6 January 2008

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24 March 2018

published in

Nature Immunology

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24 March 2018

volume

9

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24 March 2018

issue

2

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24 March 2018

page(s)

203-215

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24 March 2018

Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function

cites work

1 reference

Diversification of haematopoietic stem cells to specific lineages.

21 January 2018

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7 January 2021

Contingent gene regulatory networks and B cell fate specification

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7 January 2021

Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors

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7 January 2021

The transcriptional regulation of B cell lineage commitment.

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7 January 2021

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

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Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors

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7 January 2021

Early hematopoietic lineage restrictions directed by Ikaros.

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7 January 2021

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

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7 January 2021

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

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7 January 2021

Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.

1 reference

7 January 2021

PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors

1 reference

7 January 2021

Assembling a gene regulatory network for specification of the B cell fate

1 reference

7 January 2021

Failure of B-cell differentiation in mice lacking the transcription factor EBF.

1 reference

7 January 2021

The helix-loop-helix gene E2A is required for B cell formation

1 reference

7 January 2021

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1 reference

7 January 2021

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1 reference

7 January 2021

Helix-loop-helix proteins and lymphocyte development

1 reference

7 January 2021

Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression

1 reference

7 January 2021

The function of E- and Id proteins in lymphocyte development

1 reference

7 January 2021

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

1 reference

7 January 2021

Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments

1 reference

7 January 2021

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1 reference

7 January 2021

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

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7 January 2021

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

1 reference

7 January 2021

Reversion of B cell commitment upon loss of Pax5 expression

1 reference

7 January 2021

Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells

1 reference

7 January 2021

Pax5: the guardian of B cell identity and function

1 reference

7 January 2021

Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors

1 reference

7 January 2021

IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF.

1 reference

7 January 2021

Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A

1 reference

7 January 2021

Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.

1 reference

7 January 2021

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

1 reference

7 January 2021

Expression of CD27 on murine hematopoietic stem and progenitor cells

1 reference

7 January 2021

Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

1 reference

7 January 2021

Early B-cell factor 'pioneers' the way for B-cell development

1 reference

7 January 2021

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

1 reference

7 January 2021

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

1 reference

7 January 2021

Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.

1 reference

7 January 2021

Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

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7 January 2021

Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

1 reference

7 January 2021

Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage

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7 January 2021

Lineage specification and plasticity in CD19- early B cell precursors

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7 January 2021

Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I-cell clones

1 reference

7 January 2021

Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent

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7 January 2021

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors

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7 January 2021

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates

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7 January 2021

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene

1 reference

7 January 2021

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5

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7 January 2021

Transcription factor dosage affects changes in higher order chromatin structure associated with activation of a heterochromatic gene

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7 January 2021

Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.

1 reference

7 January 2021

Constitutive expression of the Id1 gene impairs mouse B cell development

1 reference

7 January 2021

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

1 reference

7 January 2021

Shaping a helper T cell identity

1 reference

7 January 2021

Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

1 reference

7 January 2021

Thymopoiesis independent of common lymphoid progenitors

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7 January 2021

Circulating hematopoietic progenitors with T lineage potential

1 reference

7 January 2021

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis

1 reference

7 January 2021

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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7 January 2021

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription

1 reference

7 January 2021

Analysis of the B-cell progenitor compartment at the level of single cells.

1 reference

7 January 2021

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

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7 January 2021

Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI1555

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24 March 2018

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24 March 2018