(Q50948674)

25 March 2018

title

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. (English)

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25 March 2018

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4

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author name string

Tokio Matsuzaki

1

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25 March 2018

Takehiko Matsushita

2

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25 March 2018

Koji Takayama

3

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Kotaro Nishida

5

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Ryosuke Kuroda

6

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Masahiro Kurosaka

7

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language of work or name

English

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publication date

30 May 2013

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25 March 2018

Annals of the Rheumatic Diseases

published in

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25 March 2018

volume

73

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issue

7

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25 March 2018

page(s)

1397-1404

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25 March 2018

Osteoarthritis: pathobiology-targets and ways for therapeutic intervention

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

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NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

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SIRT1 and insulin resistance

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21 January 2018

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Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity

21 January 2018

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The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity

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Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.

21 January 2018

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Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase

21 January 2018

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SIRT1 regulation of apoptosis of human chondrocytes

21 January 2018

1 reference

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SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway.

21 January 2018

1 reference

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SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes.

21 January 2018

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Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice.

21 January 2018

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Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

21 January 2018

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Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation

21 January 2018

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Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor.

21 January 2018

1 reference

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SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice.

21 January 2018

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Osteoarthritis cartilage histopathology: grading and staging.

21 January 2018

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

1 reference

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Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response

21 January 2018

1 reference

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SIRT1 promotes DNA repair activity and deacetylation of Ku70

21 January 2018

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Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

21 January 2018

1 reference

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Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

21 January 2018

1 reference

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75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

21 January 2018

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Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals

21 January 2018

1 reference

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Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

21 January 2018

1 reference

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TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-202620

Progressive loss of SIRT1 with cell cycle withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-202620

SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons

21 January 2018

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Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction.

21 January 2018

1 reference

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The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2012-202620

10.1136/ANNRHEUMDIS-2012-202620

21 January 2018

Identifiers

DOI

1 reference

25 March 2018

PubMed ID

23723318

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25 March 2018