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The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity
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review article
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title
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity
(English)
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stated in
PubMed
author name string
Akiko Satoh
series ordinal
1
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stated in
Crossref
Liana Stein
series ordinal
2
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stated in
Crossref
Shin Imai
series ordinal
3
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stated in
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language of work or name
English
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PubMed
publication date
2011
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published in
Handbook of experimental pharmacology
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PubMed
volume
206
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PubMed
page(s)
125-62
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PubMed
cites work
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SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
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Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
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DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
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JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
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Biochemical effects of SIRT1 activators
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PubMed Central
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Caloric restriction delays disease onset and mortality in rhesus monkeys
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
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Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
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21 March 2017
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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PubMed Central
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21 March 2017
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
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PubMed Central
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21 March 2017
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
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PubMed Central
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21 March 2017
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism
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PubMed Central
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21 March 2017
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
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PubMed Central
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21 March 2017
miR-34a repression of SIRT1 regulates apoptosis
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PubMed Central
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21 March 2017
PRDM16 controls a brown fat/skeletal muscle switch
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PubMed Central
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21 March 2017
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
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PubMed Central
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21 March 2017
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
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PubMed Central
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21 March 2017
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
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PubMed Central
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21 March 2017
Negative regulation of the deacetylase SIRT1 by DBC1
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PubMed Central
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21 March 2017
DBC1 is a negative regulator of SIRT1
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PubMed Central
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21 March 2017
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
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PubMed Central
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21 March 2017
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme
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PubMed Central
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21 March 2017
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
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PubMed Central
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21 March 2017
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
1 reference
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PubMed Central
reference URL
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21 March 2017
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
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PubMed Central
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21 March 2017
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
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PubMed Central
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21 March 2017
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
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PubMed Central
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21 March 2017
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
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PubMed Central
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21 March 2017
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
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PubMed Central
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21 March 2017
Obesity and metabolic syndrome in circadian Clock mutant mice
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PubMed Central
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21 March 2017
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
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PubMed Central
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21 March 2017
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
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PubMed Central
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21 March 2017
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
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PubMed Central
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21 March 2017
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
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PubMed Central
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21 March 2017
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases
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PubMed Central
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21 March 2017
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
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PubMed Central
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21 March 2017
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Structure of the histone deacetylase SIRT2
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PubMed Central
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21 March 2017
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
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PubMed Central
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21 March 2017
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
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PubMed Central
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21 March 2017
Structure and autoregulation of the yeast Hst2 homolog of Sir2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Structure of a Sir2 enzyme bound to an acetylated p53 peptide
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Crystal structure of a SIR2 homolog-NAD complex
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Resveratrol improves health and survival of mice on a high-calorie diet
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
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PubMed Central
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21 March 2017
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
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21 March 2017
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
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PubMed Central
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21 March 2017
MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
Mechanism of human SIRT1 activation by resveratrol
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21 March 2017
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
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21 March 2017
Substrate-specific activation of sirtuins by resveratrol
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
The Sir2 family of protein deacetylases
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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21 March 2017
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
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21 March 2017
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
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21 March 2017
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex
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21 March 2017
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
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21 March 2017
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
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21 March 2017
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
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21 March 2017
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
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21 March 2017
Visfatin: a new player in mesangial cell physiology and diabetic nephropathy
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21 March 2017
Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
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21 March 2017
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
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21 March 2017
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity
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21 March 2017
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
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21 March 2017
SIRT1 transgenic mice show phenotypes resembling calorie restriction
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7 April 2017
Functional brown adipose tissue in healthy adults
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7 April 2017
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
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7 April 2017
Recent progress in the biology and physiology of sirtuins
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7 April 2017
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
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7 April 2017
The meter of metabolism
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7 April 2017
Unexpected evidence for active brown adipose tissue in adult humans
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7 April 2017
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7 April 2017
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
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7 April 2017
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
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7 April 2017
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
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7 April 2017
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
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7 April 2017
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
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7 April 2017
The genetics of caloric restriction in Caenorhabditis elegans
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7 April 2017
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935
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7 April 2017
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
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7 April 2017
The endocrine regulation of aging by insulin-like signals
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9 May 2017
Structural biology of human metal-dependent histone deacetylases
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28 September 2017
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
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28 September 2017
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
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28 September 2017
Longevity and lifespan control in mammals: Lessons from the mouse
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28 September 2017
SIRT1 is essential for normal cognitive function and synaptic plasticity
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28 September 2017
Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass
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28 September 2017
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells
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28 September 2017
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
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28 September 2017
Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease
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28 September 2017
Brown adipose tissue--a new role in humans?
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28 September 2017
Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide
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28 September 2017
Transcriptional control of brown fat development
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28 September 2017
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
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28 September 2017
Sirt1 activation protects the mouse renal medulla from oxidative injury
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28 September 2017
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
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28 September 2017
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
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28 September 2017
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
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28 September 2017
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
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28 September 2017
A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
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28 September 2017
C/EBPalpha regulates SIRT1 expression during adipogenesis
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28 September 2017
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function
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28 September 2017
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice
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28 September 2017
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
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28 September 2017
Hypothalamic Sirt1 regulates food intake in a rodent model system
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28 September 2017
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
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28 September 2017
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
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28 September 2017
The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
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28 September 2017
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
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28 September 2017
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
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28 September 2017
Skeletal muscle NAMPT is induced by exercise in humans
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28 September 2017
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1.
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28 September 2017
SIRT1 genetic variation is related to BMI and risk of obesity
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28 September 2017
p30 DBC is a potential regulator of tumorigenesis
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28 September 2017
The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus
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28 September 2017
SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.
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28 September 2017
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
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28 September 2017
Metabolic benefits from Sirt1 and Sirt1 activators
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28 September 2017
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
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28 September 2017
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
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28 September 2017
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
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28 September 2017
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
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28 September 2017
The importance of NAD in multiple sclerosis
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28 September 2017
Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.
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28 September 2017
The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance
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28 September 2017
Nampt: linking NAD biology, metabolism and cancer
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28 September 2017
Phosphorylation regulates SIRT1 function.
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28 September 2017
Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction
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28 September 2017
Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway
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28 September 2017
Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase.
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28 September 2017
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
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28 September 2017
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.
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28 September 2017
The ups and downs of SIRT1.
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28 September 2017
Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Sirt1 protects against high-fat diet-induced metabolic damage
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Central control of thermogenesis in mammals
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition
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PubMed Central
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28 September 2017
SirT1 regulates energy metabolism and response to caloric restriction in mice
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Characterization of NAD uptake in mammalian cells
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PubMed Central
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28 September 2017
NAD+ and vitamin B3: from metabolism to therapies
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
High-fat diet disrupts behavioral and molecular circadian rhythms in mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Sirtuins: the 'magnificent seven', function, metabolism and longevity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
The role of nuclear architecture in genomic instability and ageing
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Cytoplasm-localized SIRT1 enhances apoptosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Resveratrol stimulates AMP kinase activity in neurons
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Transgenic mice with a reduced core body temperature have an increased life span
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Caspase-mediated changes in Sir2alpha during apoptosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Liver X receptors as integrators of metabolic and inflammatory signaling
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
The many faces of PPARgamma
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Anatomy and regulation of the central melanocortin system
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Calorie restriction extends yeast life span by lowering the level of NADH.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Diabetes mellitus and genetically programmed defects in beta-cell function
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Relationship between fatty acids and the endocrine system
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
CREB: a mediator of long-term memory from mollusks to mammals
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Regulation of hepatic fatty acid oxidation and ketone body production
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Nitrogen metabolism in liver: structural and functional organization and physiological relevance
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Activation of mating type genes by transposition in Saccharomyces cerevisiae
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 September 2017
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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31 May 2018
Tissue-specific regulation of SIRT1 by calorie restriction
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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31 May 2018
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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31 May 2018
Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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31 May 2018
Diet-induced type II diabetes in C57BL/6J mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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31 May 2018
Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
Overexpression of visfatin/PBEF/Nampt alters whole-body insulin sensitivity and lipid profile in rats
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.
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28 November 2018
DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse.
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28 November 2018
Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice.
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28 November 2018
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
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28 November 2018
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3745303
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28 November 2018
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
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28 November 2018
Diabetes, obesity, and the brain
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28 November 2018
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.
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28 November 2018
Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation
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28 November 2018
Structural basis for the mechanism and regulation of Sir2 enzymes.
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28 November 2018
Increased risk of type 2 diabetes in Alzheimer disease
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28 November 2018
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
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28 November 2018
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
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28 November 2018
Diabetes mellitus and the risk of dementia: The Rotterdam Study.
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28 November 2018
CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis i
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28 November 2018
The risk of dementia among persons with diabetes mellitus: a population-based cohort study.
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28 November 2018
Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
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28 November 2018
Adipose tissue as an endocrine and paracrine organ
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Increase in activity during calorie restriction requires Sirt1
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Insulin-like effects of visfatin on human osteoblasts
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21879449
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21879449
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21879449
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21879449
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1007/978-3-642-21631-2_7
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4350770
OpenCitations bibliographic resource ID
4350770
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4350770
PMC publication ID
3745303
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4350770
PubMed publication ID
21879449
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4350770
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