(Q50962093)

11 June 2018

title

Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. (English)

1 reference

11 June 2018

cryogenic electron microscopy

main subject

0 references

2

Roderick MacKinnon

1 reference

11 June 2018

Ji Sun

1

1 reference

11 June 2018

language of work or name

English

0 references

publication date

1 June 2017

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11 June 2018

published in

Cell

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11 June 2018

volume

169

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11 June 2018

issue

6

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11 June 2018

page(s)

1042-1050.e9

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11 June 2018

Structural Titration of Slo2.2, a Na+-Dependent K+ Channel

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14 June 2018

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14 June 2018

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14 June 2018

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Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

14 June 2018

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Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism

14 June 2018

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Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders

14 June 2018

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Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G

14 June 2018

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Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel

14 June 2018

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Alignment of cryo-EM movies of individual particles by optimization of image translations.

14 June 2018

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Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

14 June 2018

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PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6.

14 June 2018

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Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin

14 June 2018

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14 June 2018

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14 June 2018

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14 June 2018

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PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

14 June 2018

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Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

14 June 2018

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Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks)

14 June 2018

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Collaboration gets the most out of software

14 June 2018

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One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions

14 June 2018

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14 June 2018

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Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.

14 June 2018

1 reference

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RELION: implementation of a Bayesian approach to cryo-EM structure determination

14 June 2018

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Crystallographic basis for calcium regulation of sodium channels

14 June 2018

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A Bayesian view on cryo-EM structure determination.

14 June 2018

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14 June 2018

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14 June 2018

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14 June 2018

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14 June 2018

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Voltage-gated potassium channels as therapeutic targets

14 June 2018

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The genetic basis of long QT and short QT syndromes: a mutation update

14 June 2018

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14 June 2018

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14 June 2018

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Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

14 June 2018

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14 June 2018

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PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

14 June 2018

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14 June 2018

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Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins

14 June 2018

1 reference

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Differential roles of S6 domain hinges in the gating of KCNQ potassium channels.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5562354

The KCNQ1 potassium channel: from gene to physiological function

14 June 2018

1 reference

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Pathways modulating neural KCNQ/M (Kv7) potassium channels

14 June 2018

1 reference

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14 June 2018

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Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

14 June 2018

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14 June 2018

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14 June 2018

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Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.

14 June 2018

1 reference

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The open pore conformation of potassium channels

14 June 2018

1 reference

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Scanning the intracellular S6 activation gate in the shaker K+ channel

14 June 2018

1 reference

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14 June 2018

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14 June 2018

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Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

14 June 2018

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K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

14 June 2018

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14 June 2018

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14 June 2018

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14 August 2018

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Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes

14 August 2018

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KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin.

14 August 2018

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14 August 2018

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14 August 2018

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PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents

14 August 2018

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14 August 2018

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Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.

14 August 2018

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11 October 2022

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11 October 2022

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11 October 2022

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Identifiers

DOI

10.1016/J.CELL.2017.05.019

1 reference

11 June 2018

PMC publication ID

5562354

1 reference

11 June 2018

PubMed publication ID

28575668

1 reference

11 June 2018