(Q51066350)

28 March 2018

title

Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster. (English)

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28 March 2018

main subject

validamycin A

2 references

Streptomyces hygroscopicus

ChEBI release 2020-05-28

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ChEBI release 2020-05-28

ChEBI ID

90869

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inferred from

reverse claim

2-[2,3-Dihydroxy-6-(hydroxymethyl)-4-[[4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]cyclohexoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

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3

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28 March 2018

author name string

Tan-Che Zhou

series ordinal

1

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28 March 2018

Byung-Gee Kim

series ordinal

2

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28 March 2018

language of work or name

English

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publication date

25 July 2014

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28 March 2018

Applied Microbiology and Biotechnology

published in

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28 March 2018

volume

98

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28 March 2018

issue

18

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28 March 2018

page(s)

7911-7922

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28 March 2018

https://scigraph.springernature.com/pub.10.1007/s00253-014-5943-9

exact match

0 references

cites work

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Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

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Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China

21 January 2018

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Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus.

21 January 2018

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Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells

21 January 2018

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Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

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Combined gene cluster engineering and precursor feeding to improve gougerotin production in Streptomyces graminearus.

21 January 2018

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A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.

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Effect of fermentation temperature on validamycin A production by Streptomyces hygroscopicus 5008.

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Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site

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Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector

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A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor

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ZouA, a putative relaxase, is essential for dna amplification in Streptomyces kanamyceticus

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Exogenous 1,4-butyrolactone stimulates A-factor-like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008.

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Impact of nitrogen concentration on validamycin A production and related gene transcription in fermentation of Streptomyces hygroscopicus 5008.

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Spontaneous amplification of the actinorhodin gene cluster in Streptomyces coelicolor involving native insertion sequence IS466

21 January 2018

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Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008.

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Amplification of the entire kanamycin biosynthetic gene cluster during empirical strain improvement of Streptomyces kanamyceticus

21 January 2018

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Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008

21 January 2018

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Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008.

21 January 2018

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Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.

21 January 2018

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Enhanced production of validamycin A by H2O2-induced reactive oxygen species in fermentation of Streptomyces hygroscopicus 5008

21 January 2018

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Temperature shift-induced reactive oxygen species enhanced validamycin A production in fermentation of Streptomyces hygroscopicus 5008

21 January 2018

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Enhancement of validamycin A production by addition of ethanol in fermentation of Streptomyces hygroscopicus 5008

21 January 2018

1 reference

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10.1007/S00253-014-5943-9

21 January 2018

Identifiers

DOI

1 reference

28 March 2018

1 reference

28 March 2018