(Q53421286)

English

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.

scientific article published on 8 June 2011

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scholarly article

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253. (English)

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Streptomyces hygroscopicus

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Streptomyces rapamycinicus

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Streptomyces iranensis

1 reference

1 reference

1 reference

author name string

Won Seok Jung

1

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Young Ji Yoo

2

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Je Won Park

3

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Sung Ryeol Park

4

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Ah Reum Han

5

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Yeon Hee Ban

6

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Eun Ji Kim

7

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Eunji Kim

8

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Yeo Joon Yoon

9

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

language of work or name

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publication date

8 June 2011

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Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

Applied Microbiology and Biotechnology

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Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

91

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Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

5

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

1389-1397

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

https://scigraph.springernature.com/pub.10.1007/s00253-011-3348-6

0 references

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Genetic methods and strategies for secondary metabolite yield improvement in actinomycetes

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Generation of high-yield rapamycin-producing strains through protoplasts-related techniques

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Rapamycin biosynthesis: Elucidation of gene product function.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography-electrospray ionization-mass spectrometry.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2).

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Systems biology of antibiotic production by microorganisms

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

A high-throughput method for screening of rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization.

1 reference

https://api.crossref.org/works/10.1007%2FS00253-011-3348-6

21 January 2018

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.28.727

Insertional Inactivation of Methylmalonyl Coenzyme A (CoA) Mutase and Isobutyryl-CoA Mutase Genes in Streptomyces cinnamonensis: Influence on Polyketide Antibiotic Biosynthesis

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.181.18.5600-5605.1999

Identifiers

10.1007/S00253-011-3348-6

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

1 reference

Europe PubMed Central

14 May 2018

http://europepmc.org/abstract/MED/21655985

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