(Q51103780)

29 March 2018

title

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus. (English)

1 reference

29 March 2018

author

Rose Zamoyska

4

1 reference

29 March 2018

author name string

Bommhardt U

1

1 reference

29 March 2018

Cole MS

2

1 reference

29 March 2018

Tso JY

3

1 reference

29 March 2018

language of work or name

English

0 references

publication date

1 May 1997

1 reference

29 March 2018

European Journal of Immunology

published in

1 reference

29 March 2018

volume

27

1 reference

29 March 2018

issue

5

1 reference

29 March 2018

page(s)

1152-1163

1 reference

29 March 2018

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

cites work

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

The selection of the α,β heterodimeric T-cell receptor for antigen

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Another view of the selective model of thymocyte selection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Development of mature CD8+ thymocytes: selection rather than instruction?

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Cell-surface markers on haemopoietic precursors. Reagents for the isolation and analysis of progenitor cell subpopulations.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

T-cell receptor-specific monoclonal antibodies against a V beta 11-positive mouse T-cell clone

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Co-engagement of CD8 with the T cell receptor is required for negative selection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

T cell receptor targeting to thymic cortical epithelial cells in vivo induces survival, activation and differentiation of immature thymocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Characterization of mouse CD53: epitope mapping, cellular distribution and induction by T cell receptor engagement during repertoire selection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Activation events during thymic selection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

CD69 expression during selection and maturation of CD4+8+ thymocytes.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

CD8 is needed for development of cytotoxic T cells but not helper T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Requirement for CD8 beta chain in positive selection of CD8-lineage T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830270516

7 January 2021

Identifiers

DOI

10.1002/EJI.1830270516

1 reference

29 March 2018

1 reference

29 March 2018