(Q51132932)

30 March 2018

title

FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. (English)

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30 March 2018

author name string

Xiao-Sheng Zhang

1

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30 March 2018

Hong-Dou Luo

2

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30 March 2018

Yang Tao

3

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30 March 2018

Yue-Yue Wang

4

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30 March 2018

Xin-Hang Jiang

5

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30 March 2018

Hui Jiang

6

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30 March 2018

Yong-Quan Li

7

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30 March 2018

publication date

18 October 2016

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30 March 2018

Journal of Industrial Microbiology & Biotechnology

published in

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30 March 2018

volume

43

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30 March 2018

issue

12

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30 March 2018

page(s)

1693-1703

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30 March 2018

Immunosuppressive drugs: the first 50 years and a glance forward

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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

21 January 2018

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Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).

21 January 2018

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FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.

21 January 2018

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Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems

21 January 2018

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Characterization of three positive regulators for tetramycin biosynthesis in Streptomyces ahygroscopicus.

21 January 2018

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A subfamily of MalT-related ATP-dependent regulators in the LuxR family.

21 January 2018

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Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster

21 January 2018

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Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme

21 January 2018

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Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.

21 January 2018

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FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

21 January 2018

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Origin of the allyl group in FK506 biosynthesis

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PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

21 January 2018

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A large family of bacterial activator proteins

21 January 2018

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Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117.

21 January 2018

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Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

21 January 2018

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Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.

21 January 2018

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The impact of novel immunosuppressive agents on infections in organ transplant recipients and the interactions of these agents with antimicrobials

21 January 2018

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An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units

21 January 2018

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FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

21 January 2018

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Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis.

21 January 2018

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Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector

21 January 2018

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Involvement of SigT and RstA in the differentiation of Streptomyces coelicolor

21 January 2018

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Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

21 January 2018

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Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

21 January 2018

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Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP

21 January 2018

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Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666.

21 January 2018

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Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.

21 January 2018

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The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.

21 January 2018

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Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520

21 January 2018

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The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.

21 January 2018

1 reference

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Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1849-0

Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O:methyltransferase from Streptomyces sp. MA6858.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1849-0

Discovery of topical calcineurin inhibitors and pharmacological profile of pimecrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1849-0

Characterization of type II thioesterases involved in natamycin biosynthesis in Streptomyces chattanoogensis L10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10295-016-1849-0

Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network

21 January 2018

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Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae

21 January 2018

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Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.

21 January 2018

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hmgA, transcriptionally activated by HpdA, influences the biosynthesis of actinorhodin in Streptomyces coelicolor

21 January 2018

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Biochemical characterization of a malonyl-specific acyltransferase domain of FK506 biosynthetic polyketide synthase

21 January 2018

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12 December 2020

The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR

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12 December 2020

Characterization of Lrp, and Escherichia coli regulatory protein that mediates a global response to leucine

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12 December 2020

MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator

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12 December 2020

AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli.

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12 December 2020

abaB, a putative regulator for secondary metabolism in Streptomyces

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12 December 2020

Green fluorescent protein as a reporter for spatial and temporal gene expression in Streptomyces coelicolor A3(2)

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12 December 2020

10.1007/S10295-016-1849-0

Identifiers

DOI

1 reference

30 March 2018

PubMed ID

27757551

1 reference

30 March 2018