(Q51281687)

2 April 2018

title

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation. (English)

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2

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Luigi Tornillo

8

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Markus H Heim

10

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Giovanna Muscogiuri

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Giovanna Muscogiuri

6

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Fabio Marra

object named as

Fabio Marra

9

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author name string

Christine Bernsmeier

1

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2 April 2018

Angela Provenzano

3

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Zuzanna Makowska

4

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Ilona Krol

5

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David Semela

7

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François H T Duong

11

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publication date

18 July 2016

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2 April 2018

published in

Laboratory Investigation

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volume

96

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issue

9

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page(s)

972-980

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https://scigraph.springernature.com/pub.10.1038/labinvest.2016.75

exact match

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cites work

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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

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In brief: Notch signalling in health and disease

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Notch signaling at a glance

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The F-box protein Fbw7 is required for cerebellar development.

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Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling

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Constitutive Notch2 signaling induces hepatic tumors in mice

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Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice

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Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

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Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

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Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance

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Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

21 January 2018

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Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

21 January 2018

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

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Summaries of Affymetrix GeneChip probe level data

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Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences.

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The role of FoxO in the regulation of metabolism.

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Insulin sensitivity: modulation by nutrients and inflammation

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The role of lipid droplets in metabolic disease in rodents and humans

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Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice

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Abnormal differentiation of intestinal epithelium and intestinal barrier dysfunction in diabetic mice associated with depressed Notch/NICD transduction in Notch/Hes1 signal pathway

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27428080

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12 December 2020

based on heuristic

NAFLD. Metabolic make-up of NASH: from fat and sugar to amino acids

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27428080

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LABINVEST.2016.75

1 reference

2 April 2018

PubMed ID

27428080

1 reference

2 April 2018