(Q51370640)

4 April 2018

title

Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. (English)

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5

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Anna K Clark

object named as

Anna K Clark

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Mauro Perretti

4

object named as

Mauro Perretti

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author name string

John Grist

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Adam Al-Kashi

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publication date

27 December 2011

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published in

Arthritis & Rheumatology

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volume

64

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issue

6

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page(s)

2038-2047

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Collagen arthritis as a relevant model for rheumatoid arthritis

cites work

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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

21 January 2018

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The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

21 January 2018

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Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor

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Inhibition of fractalkine ameliorates murine collagen-induced arthritis.

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Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing

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Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates

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Microglial signalling mechanisms: Cathepsin S and Fractalkine

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Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.

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T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity.

21 January 2018

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21 January 2018

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Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

21 January 2018

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Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis

21 January 2018

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Cathepsin S activity regulates antigen presentation and immunity

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21 January 2018

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21 January 2018

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Fractalkine/CX3CR1 signalling in chronic pain and inflammation

21 January 2018

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Role of spinal microglia in rat models of peripheral nerve injury and inflammation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.34351

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4 April 2018

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4 April 2018