Wikidata

(Q5145884)

English

collagen type I alpha 1 chain

mammalian protein found in Homo sapiens

  • pro-alpha-1 collagen type 1
  • collagen of skin, tendon and bone, alpha-1 chain
  • alpha-1 type I collagen
  • collagen, type I, alpha 1
  • collagen alpha-1(I) chain
  • type I proalpha 1
  • type I procollagen alpha 1 chain
  • COL1A1
  • alpha1(I) procollagen
  • collagen alpha 1 chain type I
  • collagen alpha-1(I) chain preproprotein
In more languages

Statements

molecular function
protein binding
determination method
IPI
5 references
retrieved
8 April 2019
stated in
TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis
GOA
curator
UniProt
UniProt protein ID
P02452
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IPI
retrieved
8 April 2019
stated in
Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta
GOA
curator
UniProt
UniProt protein ID
P02452
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IPI
retrieved
8 April 2019
stated in
Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IPI
retrieved
8 April 2019
stated in
Structural and functional analysis of the fibronectin-binding protein FNE from Streptococcus equi spp. equi
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IPI
retrieved
8 April 2019
stated in
Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IPI
extracellular matrix structural constituent conferring tensile strength
determination method
HDA
ISS
6 references
retrieved
1 January 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
ISS
retrieved
1 January 2018
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
1 January 2018
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
1 January 2018
stated in
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
1 January 2018
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
HDA
extracellular matrix structural constituent conferring tensile strength
determination method
IEA
ISS
RCA
13 references
retrieved
1 January 2018
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
1 January 2018
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
1 January 2018
stated in
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
1 January 2018
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
1 January 2018
stated in
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
1 January 2018
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
ISS
retrieved
1 January 2018
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
1 January 2018
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
1 January 2018
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
1 January 2018
stated in
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
1 January 2018
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
1 January 2018
stated in
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
extracellular matrix structural constituent conferring tensile strength
determination method
HDA
ISS
RCA
7 references
retrieved
8 April 2019
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
8 April 2019
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
8 April 2019
stated in
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
8 April 2019
stated in
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
8 April 2019
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
RCA
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
ISS
retrieved
8 April 2019
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
cell component
extracellular matrix
determination method
IDA
ISS
IEA
5 references
retrieved
17 October 2017
stated in
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
ISS
retrieved
17 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
17 October 2017
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P02452
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
IDA
retrieved
17 October 2017
stated in
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
IDA
retrieved
17 October 2017
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P02452&geneProductId=UniProtKB:P02452
determination method
IDA
collagen-containing extracellular matrix
determination method
HDA
ISS
8 references
retrieved
8 April 2019
stated in
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
ISS
retrieved
8 April 2019
stated in
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance
GOA
curator
UniProt
UniProt protein ID
P02452
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
8 April 2019
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
8 April 2019
stated in
Proteomics characterization of extracellular space components in the human aorta
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
8 April 2019
stated in
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
8 April 2019
stated in
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
8 April 2019
stated in
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
retrieved
8 April 2019
stated in
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
HDA
biological process
skeletal system development
determination method
IBA
IEA
IMP
5 references
retrieved
8 April 2019
stated in
Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix
GOA
curator
UniProt
UniProt protein ID
P02452
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IMP
retrieved
8 April 2019
stated in
Gene targeting in stem cells from individuals with osteogenesis imperfecta
GOA
curator
UniProt
UniProt protein ID
P02452
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IMP
retrieved
8 April 2019
stated in
Homology-mediated recombination between type I collagen gene exons results in an internal tandem duplication and lethal osteogenesis imperfecta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02452
determination method
IBA
Gene Atlas image
PBB GE COL1A1 202310 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D000090602
subject named as
Collagen Type I, alpha 1 Chain
0 references
Freebase ID
/m/09h1wc
0 references
 
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