(Q51538182)

6 April 2018

title

Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity. (English)

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6 April 2018

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Daniel J Sexton

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6 April 2018

author name string

René Michael Hoet

1

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6 April 2018

Edward H Cohen

2

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Rachel Baribault Kent

3

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Kristin Rookey

4

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Sonia Schoonbroodt

5

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Shannon Hogan

6

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Louise Rem

7

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Nicolas Frans

8

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Marc Daukandt

9

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Henk Pieters

10

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Rob van Hegelsom

11

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Nicole Coolen-van Neer

12

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Horacio G Nastri

13

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Isaac J Rondon

14

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Jennifer A Leeds

15

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Simon E Hufton

16

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Lili Huang

17

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Irina Kashin

18

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Mary Devlin

19

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Guannan Kuang

20

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Mieke Steukers

21

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Malini Viswanathan

22

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Andrew E Nixon

23

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Hennie R Hoogenboom

25

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Robert Charles Ladner

26

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6 April 2018

publication date

20 February 2005

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6 April 2018

published in

Nature Biotechnology

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6 April 2018

volume

23

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6 April 2018

issue

3

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6 April 2018

page(s)

344-348

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6 April 2018

Recombinant antibodies for cancer diagnosis and therapy

cites work

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Binding to CD20 by anti-B1 antibody or F(ab')(2) is sufficient for induction of apoptosis in B-cell lines

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Comparable heavy and light chain pairings in normal and systemic lupus erythematosus IgG(+) B cells.

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Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis

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7 January 2021

Three-dimensional structure of an Fv from a human IgM immunoglobulin

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7 January 2021

Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions

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7 January 2021

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7 January 2021

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem

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7 January 2021

Kabat Database and its applications: 30 years after the first variability plot

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7 January 2021

Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures

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7 January 2021

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

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7 January 2021

High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold

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7 January 2021

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7 January 2021

Human combinatorial Fab library yielding specific and functional antibodies against the human fibroblast growth factor receptor 3.

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7 January 2021

A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies

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7 January 2021

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

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7 January 2021

Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

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7 January 2021

Preferred CDRH3 lengths for antibodies with defined specificities

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7 January 2021

The Remarkable Flexibility of the Human Antibody Repertoire; Isolation of Over One Thousand Different Antibodies to a Single Protein, BLyS

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7 January 2021

Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries

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7 January 2021

Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries

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7 January 2021

High efficiency transformation of E. coli by high voltage electroporation

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7 January 2021

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site

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7 January 2021

Identifiers

DOI

10.1038/NBT1067

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6 April 2018

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6 April 2018