(Q51690060)

9 April 2018

title

Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice. (English)

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9 April 2018

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George Davey Smith

1

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publication date

1 June 2011

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9 April 2018

International Journal of Epidemiology

published in

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9 April 2018

volume

40

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9 April 2018

issue

3

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9 April 2018

page(s)

537-562

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9 April 2018

Genome-wide association studies may be misinterpreted: genes versus heritability

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Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland

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Otitis media: genetic factors and sex differences.

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Heritability of Recurrent Tonsillitis

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Mutans streptococci in preschool twins

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Increased concordance of severe respiratory syncytial virus infection in identical twins

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The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies

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Maternal smoking during pregnancy and intellectual performance in young adult Swedish male offspring

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Nonshared environment: a theoretical, methodological, and quantitative review

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Why are children in the same family so different? Nonshared environment a decade later

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Is birth order associated with adult mortality?

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Influence of family size and birth order on risk of cancer: a population-based study

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A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the mother

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Birth order and childhood type 1 diabetes risk: a pooled analysis of 31 observational studies

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Birth order and risk of non-hodgkin lymphoma--true association or bias?

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A Systematic Review and Meta-analysis of Northern Hemisphere Season of Birth Studies in Schizophrenia

21 January 2018

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The genetics of obesity: what have genetic studies told us about the environment

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A longitudinal behavioral genetic analysis of the etiology of aggressive and nonaggressive antisocial behavior

21 January 2018

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Personal genomes: The case of the missing heritability

21 January 2018

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Variance components models for gene-environment interaction in twin analysis.

21 January 2018

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Heritability in the genomics era — concepts and misconceptions

21 January 2018

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The Body-Mass Index of Twins Who Have Been Reared Apart

21 January 2018

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The nature of environmental influences on weight and obesity: a behavior genetic analysis

21 January 2018

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Genetic and environmental contributions to body mass index: comparative analysis of monozygotic twins, dizygotic twins and same-age unrelated siblings.

21 January 2018

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Hundreds of variants clustered in genomic loci and biological pathways affect human height

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Common SNPs explain a large proportion of the heritability for human height

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Synthetic associations in the context of genome-wide association scan signals

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic and environmental determinants of musical ability in twins

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Confirming the etiology of adolescent acting-out behaviors: an examination of observer-ratings in a sample of adoptive and biological siblings

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic factors in the aetiology of mouth ulcers.

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Environmental influences on children's physical activity: quantitative estimates using a twin design

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic influences on 'environmental' factors

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Implications of the restricted range of family environments for estimates of heritability and nonshared environment in behavior-genetic adoption studies

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Heritability for adolescent antisocial behavior differs with socioeconomic status: gene-environment interaction.

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Rethinking environmental contributions to child and adolescent psychopathology: A meta-analysis of shared environmental influences

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Sifting the evidence-what's wrong with significance tests?

21 January 2018

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Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs

21 January 2018

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A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine1

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Production of different phenotypes from the same genotype in the same environment by developmental variation

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

A third source of developmental differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Nonlinear epigenetic variance: review and simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

DEVELOPMENTAL NOISE, PHENOTYPIC PLASTICITY, AND ALLOZYME HETEROZYGOSITY IN DAPHNIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Stochasticity or the fatal 'imperfection' of cloning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Stochasticity in gene expression: from theories to phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Stochastic gene expression in fluctuating environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Phenotypic differences in genetically identical organisms: the epigenetic perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Epigenetics and phenotypic variation in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Random monoallelic expression: making a choice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Allele-specific methylation in the human genome: implications for genetic studies of complex disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Epigenetics and environment: a complex relationship.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

DNA methylation profiles in monozygotic and dizygotic twins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Optimal Mixed Strategies in Stochastic Environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Phenotypic diversity, population growth, and information in fluctuating environments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Functional roles for noise in genetic circuits

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Experimental evolution of bet hedging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Phenotypic consequences of promoter-mediated transcriptional noise

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

A longitudinal study of epigenetic variation in twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

The evolutionary genetics of canalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Sick individuals and sick populations

21 January 2018

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Is Indeterminism the Source of the Statistical Character of Evolutionary Theory?

21 January 2018

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Careful use of pseudo R-squared measures in epidemiological studies

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Cancer risk assessment and prevention: where do we stand?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

The age distribution of cancer and a multi-stage theory of carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Commentary: The age distribution of cancer and a multistage theory of carcinogenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Cigarette smoking and site-specific cancer mortality: testing uncertain associations using extended follow-up of the original Whitehall study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

The Correlation between Relatives on the Supposition of Mendelian Inheritance

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Epidemiology in a changing world: variation, causation and ubiquitous risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

21 January 2018

1 reference

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Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Random allocation in observational data: how small but robust effects could facilitate hypothesis-free causal inference

21 January 2018

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The limits of lifestyle: re-assessing 'fatalism' in the popular culture of illness prevention

21 January 2018

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Inheriting heart trouble: the relevance of common-sense ideas to preventive measures

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

21 January 2018

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Weismann Rules! OK? Epigenetics and the Lamarckian temptation

21 January 2018

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Three Laws of Behavior Genetics and What They Mean

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Heritability and shared genetic effects of asthma and hay fever: an Italian study of young twins

21 January 2018

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Genetic Influence on Human Psychological Traits

21 January 2018

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The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

21 January 2018

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A genetic and environmental time series analysis of blood pressure in male twins

21 January 2018

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Evidence for genetic influences on sleep disturbance and sleep pattern in twins

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic and environmental contributions to general cognitive ability through the first 16 years of life

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

An Adoption Study of the Etiology of Teacher and Parent Reports of Externalizing Behavior Problems in Middle Childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Masculine Girls and Feminine Boys: Genetic and Environmental Contributions to Atypical Gender Development in Early Childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic etiology in cases of recovered and persistent stuttering in an unselected, longitudinal sample of young twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetic and Environmental Contributions to Variance in Age at First Sexual Intercourse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Heritability of autistic traits in the general population

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Applications of the concept of attributable fraction in medical genetics

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

How much can a large population study on genes, environments, their interactions and common diseases contribute to the health of the American people?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Missing heritability in genome-wide association study research

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

R. A. Fisher, Lancelot Hogben, and the origin(s) of genotype-environment interaction

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Biometric and developmental gene-environment interactions: looking back, moving forward

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Gene X environment interactions at the serotonin transporter locus

21 January 2018

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https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Gene-environment interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genetics of mouse behavior: interactions with laboratory environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Incommunicable knowledge? Interpreting and applying the results of clinical trials and meta-analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genes, environment, and individual differences in responding to treatment for depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Genome-wide pharmacogenetics of antidepressant response in the GENDEP project

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Melancholic, atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Systematic review of randomised controlled trials of multiple risk factor interventions for preventing coronary heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

How much of the recent decline in the incidence of myocardial infarction in British men can be explained by changes in cardiovascular risk factors? Evidence from a prospective population-based study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FIJE%2FDYR117

21 January 2018

Identifiers

DOI

10.1093/IJE/DYR117

1 reference

9 April 2018

1 reference

9 April 2018