(Q51755750)

11 April 2018

title

Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors. (English)

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11 April 2018

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Michael Pohlscheidt

1

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11 April 2018

Melanie Jacobs

2

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Stefan Wolf

3

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Joerg Thiele

4

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Alexander Jockwer

5

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Josef Gabelsberger

6

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Marco Jenzsch

7

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Hermann Tebbe

8

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Josef Burg

9

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publication date

17 January 2013

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11 April 2018

published in

Biotechnology Progress

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volume

29

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issue

1

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page(s)

222-229

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Monoclonal antibodies in the clinic.

cites work

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Monoclonal antibodies market

21 January 2018

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Lessons from 60 years of pharmaceutical innovation

21 January 2018

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Integrated approaches to the design of media and feeding strategies for fed-batch cultures of animal cells

21 January 2018

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Experimental and theoretical analysis of tubular membrane aeration for Mammalian cell bioreactors

21 January 2018

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Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

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Challenges in therapeutic glycoprotein production

21 January 2018

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Cell culture process development: advances in process engineering

21 January 2018

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Recent advances in large-scale production of monoclonal antibodies and related proteins

21 January 2018

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Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells

21 January 2018

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Performance of small-scale CHO perfusion cultures using an acoustic cell filtration device for cell retention: characterization of separation efficiency and impact of perfusion on product quality

21 January 2018

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Mammalian cell retention devices for stirred perfusion bioreactors

21 January 2018

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Industrial choices for protein production by large-scale cell culture

21 January 2018

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Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates

21 January 2018

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A new seed-train expansion method for recombinant mammalian cell lines

21 January 2018

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Glucose-based optimization of CHO-cell perfusion cultures

21 January 2018

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Erythropoietin production from CHO cells grown by continuous culture in a fluidized-bed bioreactor

21 January 2018

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Recombinant antibody production by perfusion cultures of rCHO cells in a depth filter perfusion system

21 January 2018

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Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems.

21 January 2018

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Perfusion culture of hybridoma cells for hyperproduction of IgG(2a) monoclonal antibody in a wave bioreactor-perfusion culture system

21 January 2018

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Separation of CHO cells using hydrocyclones.

21 January 2018

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Spin filter perfusion system for high density cell culture: production of recombinant urinary type plasminogen activator in CHO cells

21 January 2018

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Effects of elevated pCO(2) and/or osmolality on the growth and recombinant tPA production of CHO cells

21 January 2018

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Insights into large-scale cell-culture reactors: II. Gas-phase mixing and CO₂ stripping

21 January 2018

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Mammalian cell culture processes

21 January 2018

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Optimization of fed-batch parameters and harvest time of CHO cell cultures for a glycosylated product with multiple mechanisms of inactivation.

21 January 2018

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In pursuit of the optimal fed-batch process for monoclonal antibody production

21 January 2018

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Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures.

21 January 2018

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A sensitivity analysis of the fed-batch animal-cell bioreactor with respect to some control parameters.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BTPR.1672

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11 April 2018

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11 April 2018