(Q51779481)

12 April 2018

editorial

0 references

title

Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here? (English)

1 reference

12 April 2018

1 reference

Uday Saxena

1

1 reference

12 April 2018

language of work or name

English

0 references

publication date

1 December 2010

1 reference

12 April 2018

Expert Opinion on Therapeutic Targets

published in

1 reference

12 April 2018

volume

14

1 reference

12 April 2018

issue

12

1 reference

12 April 2018

page(s)

1273-1277

1 reference

12 April 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Alzhemed: a potential treatment for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Oxidative stress potentiates BACE1 gene expression and Abeta generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.528285

10.1517/14728222.2010.528285

21 January 2018

Identifiers

DOI

1 reference

12 April 2018

PubMed ID

21058918

1 reference

12 April 2018