(Q51786270)

12 April 2018

review article

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title

The future of drug development: advancing clinical trial design. (English)

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12 April 2018

author name string

John Orloff

1

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12 April 2018

Frank Douglas

2

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12 April 2018

Jose Pinheiro

3

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12 April 2018

Susan Levinson

4

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12 April 2018

Michael Branson

5

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12 April 2018

Pravin Chaturvedi

6

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12 April 2018

Ene Ette

7

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12 April 2018

Paul Gallo

8

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12 April 2018

Gigi Hirsch

9

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12 April 2018

Cyrus Mehta

10

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12 April 2018

Nitin Patel

11

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12 April 2018

Sameer Sabir

12

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12 April 2018

Stacy Springs

13

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12 April 2018

Donald Stanski

14

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12 April 2018

Matthias R Evers

15

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Edd Fleming

16

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12 April 2018

Navjot Singh

17

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Tony Tramontin

18

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Howard Golub

19

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12 April 2018

publication date

9 October 2009

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12 April 2018

Nature Reviews Drug Discovery

published in

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12 April 2018

volume

8

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12 April 2018

issue

12

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12 April 2018

page(s)

949-957

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12 April 2018

Prospects for productivity

cites work

1 reference

Can the pharmaceutical industry reduce attrition rates?

31 March 2020

1 reference

Spending on new drug development1

31 March 2020

1 reference

The price of innovation: new estimates of drug development costs

31 March 2020

1 reference

Estimating the cost of new drug development: is it really 802 million dollars?

31 March 2020

1 reference

Pharmacokinetic/pharmacodynamic modeling in drug development

31 March 2020

1 reference

Model-based drug development

31 March 2020

1 reference

Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm

31 March 2020

1 reference

Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers

31 March 2020

1 reference

Simulation of clinical trials

31 March 2020

1 reference

How modeling and simulation have enhanced decision making in new drug development

31 March 2020

1 reference

31 March 2020

1 reference

An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development. Experience within Hoffmann La Roche

31 March 2020

1 reference

Use of canakinumab in the cryopyrin-associated periodic syndrome

31 March 2020

1 reference

31 March 2020

Bayesian clinical trials

1 reference

Introduction to Bayesian methods III: use and interpretation of Bayesian tools in design and analysis

31 March 2020

1 reference

Adaptive designs in clinical drug development: opportunities, challenges, and scope reflections following PhRMA's November 2006 workshop

31 March 2020

1 reference

Adaptive designs in clinical drug development--an Executive Summary of the PhRMA Working Group

31 March 2020

1 reference

Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials

31 March 2020

1 reference

Flexible design and efficient implementation of adaptive dose-finding studies.

31 March 2020

1 reference

Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: general concepts

31 March 2020

1 reference

Adaptive, group sequential and decision theoretic approaches to sample size determination

31 March 2020

1 reference

The need for more efficient trial designs

31 March 2020

1 reference

31 March 2020

Adaptive trial design.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19816458

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3025

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12 April 2018

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12 April 2018