(Q81139396)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132354%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers (English)

1 reference

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6 January 2020

1 reference

1 reference

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Gunnar Alvan

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132354%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Svein G Dahl

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132354%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

Jochen Kuhlmann

series ordinal

4

1 reference

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6 January 2020

publication date

24 August 2005

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6 January 2020

published in

Pharmaceutical Research

1 reference

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6 January 2020

volume

22

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6 January 2020

issue

9

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6 January 2020

page(s)

1432-1437

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Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats

6 January 2020

cites work

1 reference

12 December 2020

Physiological red blood cell kinetic model to explain the apparent discrepancy between adenosine breakdown inhibition and nucleoside transporter occupancy of draflazine.

1 reference

12 December 2020

Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

1 reference

12 December 2020

Transit compartments versus gamma distribution function to model signal transduction processes in pharmacodynamics

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.

1 reference

12 December 2020

A model eliciting transient responses

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12 December 2020

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling

1 reference

12 December 2020

A mathematical model for dynamics of cardiovascular drug action: application to intravenous dihydropyridines in healthy volunteers.

1 reference

12 December 2020

Pharmacodynamic modeling of furosemide tolerance after multiple intravenous administration

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12 December 2020

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance

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12 December 2020

Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats

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12 December 2020

EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil

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12 December 2020

Drug treatment effects on disease progression.

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12 December 2020

The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model.

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12 December 2020

Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers

1 reference

12 December 2020

Biomarkers in Drug Discovery and Development: From Target Identification through Drug Marketing

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12 December 2020

Prolactin release after remoxipride by an integrated pharmacokinetic-pharmacodynamic model with intra- and interindividual aspects

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12 December 2020

Disease system analysis: basic disease progression models in degenerative disease

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo

1 reference

12 December 2020

Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans

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12 December 2020

Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling.

1 reference

12 December 2020

Hypothesis: a single clinical trial plus causal evidence of effectiveness is sufficient for drug approval

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12 December 2020

Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm

1 reference

12 December 2020

Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

1 reference

12 December 2020

Comparison of four basic models of indirect pharmacodynamic responses

1 reference

12 December 2020

Model describing the relationship between pharmacokinetics and hematologic toxicity of the epirubicin-docetaxel regimen in breast cancer patients.

1 reference

12 December 2020

Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations

1 reference

12 December 2020

Operational models of pharmacological agonism.

1 reference

12 December 2020

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.

1 reference

12 December 2020

Use of biomarkers from drug discovery through clinical practice: report of the Ninth European Federation of Pharmaceutical Sciences Conference on Optimizing Drug Development

1 reference

12 December 2020

Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients.

1 reference

12 December 2020

Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies

1 reference

12 December 2020

Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.

1 reference

12 December 2020

A system approach to pharmacodynamics. Input-effect control system analysis of central nervous system effect of alfentanil.

1 reference

12 December 2020

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

1 reference

12 December 2020

Application of pharmacodynamic modeling for designing time-variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure

1 reference

12 December 2020

A turnover model of irreversible inhibition of gastric acid secretion by omeprazole in the dog

1 reference

12 December 2020

Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat.

1 reference

12 December 2020

A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors

1 reference

12 December 2020

Diversity of mechanism-based pharmacodynamic models

1 reference

12 December 2020

Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.

1 reference

12 December 2020

Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil

1 reference

12 December 2020

The contribution of clinical pharmacology surrogates and models to drug development--a critical appraisal

1 reference

12 December 2020

10.1007/S11095-005-5882-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16132354%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference