(Q51794711)

12 April 2018

title

Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice. (English)

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12 April 2018

author name string

Christen A McAlpine

1

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12 April 2018

Yaacov Barak

2

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12 April 2018

Ilze Matise

3

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12 April 2018

Robert T Cormier

4

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12 April 2018

language of work or name

English

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publication date

1 November 2006

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12 April 2018

International Journal of Cancer

published in

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12 April 2018

volume

119

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issue

10

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12 April 2018

page(s)

2339-2346

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12 April 2018

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms

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Impairment of peroxisomal biogenesis in human colon carcinoma.

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Peroxisome proliferator-activated receptors (PPARs) and associated transcription factors in colon cancer: reduced expression of PPARgamma-coactivator 1 (PGC-1).

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A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

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Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies

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Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis

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Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis

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Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats.

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Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands

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Activators of the nuclear receptor PPARgamma enhance colon polyp formation

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Promotion of colon tumors in C57BL/6J-APC(min)/+ mice by thiazolidinedione PPARgamma agonists and a structurally unrelated PPARgamma agonist

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Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice

21 January 2018

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The Wnt/beta-catenin signaling pathway targets PPARgamma activity in colon cancer cells

21 January 2018

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Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adip

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Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway

21 January 2018

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Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand.

21 January 2018

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APC-dependent suppression of colon carcinogenesis by PPARgamma

21 January 2018

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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

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PPAR gamma is required for placental, cardiac, and adipose tissue development

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Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

21 January 2018

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Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases

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Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone

21 January 2018

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Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.

21 January 2018

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Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells

21 January 2018

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Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.

21 January 2018

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Intestinal tumours induced by the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in multiple intestinal neoplasia mice have truncation mutations as well as loss of the wild-type Apc(+) allele

21 January 2018

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Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer

21 January 2018

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Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor.

21 January 2018

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Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action

21 January 2018

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Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

21 January 2018

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Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice.

21 January 2018

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Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

21 January 2018

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Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.22115

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12 April 2018

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12 April 2018