(Q51794745)

12 April 2018

title

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. (English)

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12 April 2018

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3

Dennis J Selkoe

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12 April 2018

author name string

Matthew Townsend

series ordinal

1

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12 April 2018

Tapan Mehta

series ordinal

2

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language of work or name

English

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publication date

13 September 2007

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12 April 2018

Journal of Biological Chemistry

published in

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volume

282

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page(s)

33305-33312

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issue

46

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12 April 2018

Deciphering the genetic basis of Alzheimer's disease

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Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

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Regulation of NMDA receptor trafficking by amyloid-beta

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beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.

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Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

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Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons

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Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons

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Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

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Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

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Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

21 January 2018

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Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation

21 January 2018

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21 January 2018

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Trophic effect of glutamate

21 January 2018

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ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

21 January 2018

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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21 January 2018

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21 January 2018

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Functional properties of the subtype of insulin receptor found on neurons

21 January 2018

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Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

21 January 2018

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The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

21 January 2018

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Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration

21 January 2018

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Role for neuronal insulin resistance in neurodegenerative diseases

21 January 2018

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 January 2018

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Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M610390200

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12 April 2018

PubMed ID

17855343

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12 April 2018