(Q51798862)

12 April 2018

title

Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding. (English)

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12 April 2018

author name string

Wendy L Connors

1

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12 April 2018

Johanna Jokinen

2

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12 April 2018

Daniel J White

3

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12 April 2018

J Santeri Puranen

4

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12 April 2018

Pasi Kankaanpää

5

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12 April 2018

Paula Upla

6

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12 April 2018

Mira Tulla

7

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Mark S Johnson

8

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12 April 2018

Jyrki Heino

9

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12 April 2018

language of work or name

English

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publication date

19 March 2007

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12 April 2018

Journal of Biological Chemistry

published in

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12 April 2018

volume

282

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issue

19

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12 April 2018

page(s)

14675-14683

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12 April 2018

The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

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The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain

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Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1.

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Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.

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Activation of protein kinase C is required for the stable attachment of adherent platelets to collagen but is not needed for the initial rapid adhesion under flow conditions

21 January 2018

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Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen

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The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix

21 January 2018

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Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail

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The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation

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Integrin alphavbeta3 mediates platelet-derived growth factor-BB-stimulated collagen gel contraction in cells expressing signaling deficient integrin alpha2beta1.

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Integrin-mediated cell adhesion to type I collagen fibrils

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A highly sensitive selection method for directed evolution of homing endonucleases

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21 January 2018

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21 January 2018

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Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

21 January 2018

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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

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21 January 2018

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Two functional active conformations of the integrin {alpha}2{beta}1, depending on activation condition and cell type.

21 January 2018

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21 January 2018

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

21 January 2018

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Are changes in integrin affinity and conformation overemphasized?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700759200

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M700759200

PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic

21 January 2018

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

21 January 2018

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Organization of the integrin LFA-1 in nanoclusters regulates its activity

21 January 2018

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Avidity regulation of integrins: the driving force in leukocyte adhesion

21 January 2018

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Mechanisms contributing to the activity of integrins on leukocytes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M700759200

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12 April 2018

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12 April 2018