(Q51816199)

13 April 2018

title

Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition. (English)

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13 April 2018

3

Andreas Ebneth

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13 April 2018

author name string

Arnulf Dorn

1

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13 April 2018

Francis Hermann

2

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13 April 2018

Hendrick Bothmann

4

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13 April 2018

Gerhard Trube

5

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13 April 2018

Klaus Christensen

6

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13 April 2018

Christian Apfel

7

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13 April 2018

publication date

1 June 2005

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13 April 2018

Journal of Biomolecular Screening

published in

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13 April 2018

volume

10

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13 April 2018

issue

4

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13 April 2018

page(s)

339-347

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13 April 2018

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

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Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.

21 January 2018

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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.

21 January 2018

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QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

21 January 2018

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Molecular biology of K(+) channels and their role in cardiac arrhythmias

21 January 2018

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Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

21 January 2018

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High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide

21 January 2018

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The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis

21 January 2018

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21 January 2018

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Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction

21 January 2018

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Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1,3-dibutylbarbituric acid)trimethine oxonol (Dibac4(3)) in model systems and cells

21 January 2018

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Cell-based assays and instrumentation for screening ion-channel targets

21 January 2018

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Flow cytometric determination of absolute membrane potential of cells.

21 January 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

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ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis.

21 January 2018

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Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

21 January 2018

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Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

21 January 2018

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Functional and pharmacological properties of canine ERG potassium channels

21 January 2018

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[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

21 January 2018

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Patch clamping by numbers

21 January 2018

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Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole

21 January 2018

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The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

21 January 2018

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The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

21 January 2018

1 reference

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Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

21 January 2018

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

21 January 2018

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Effects of H1 antihistamines on animal models of QTc prolongation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1177/1087057104272045

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13 April 2018

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13 April 2018