(Q51825443)

13 April 2018

editorial

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review article

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title

Uncovering the PKR pathway's potential for treatment of tumors. (English)

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13 April 2018

author name string

Zineb Mounir

series ordinal

1

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13 April 2018

Antonis E Koromilas

series ordinal

2

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13 April 2018

language of work or name

English

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publication date

1 May 2010

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13 April 2018

published in

Future Oncology

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13 April 2018

volume

6

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13 April 2018

issue

5

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13 April 2018

page(s)

643-645

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13 April 2018

Translational control in stress and apoptosis

cites work

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Signaling control of mRNA translation in cancer pathogenesis

21 January 2018

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

21 January 2018

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PKR, apoptosis and cancer

21 January 2018

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Coping with stress: eIF2 kinases and translational control

21 January 2018

1 reference

Gene-specific regulation by general translation factors

21 January 2018

1 reference

Activation of PKR: an open and shut case?

21 January 2018

1 reference

Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

21 January 2018

1 reference

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

21 January 2018

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

21 January 2018

1 reference

Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

1 reference

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

21 January 2018

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Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

21 January 2018

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Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression

21 January 2018

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Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

21 January 2018

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Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.

21 January 2018

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

21 January 2018

1 reference

JNK2 and IKKbeta are required for activating the innate response to viral infection

21 January 2018

1 reference

Inhibition of glioma growth by tumor-specific activation of double-stranded RNA-dependent protein kinase PKR.

21 January 2018

1 reference

Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

1 reference

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

21 January 2018

1 reference

Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound

21 January 2018

1 reference

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.10.45

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13 April 2018

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13 April 2018