(Q51928851)

17 April 2018

title

Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. (English)

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17 April 2018

author name string

Robert L Walsky

series ordinal

1

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17 April 2018

Angela V Astuccio

series ordinal

2

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17 April 2018

R Scott Obach

series ordinal

3

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17 April 2018

publication date

1 December 2006

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17 April 2018

The Journal of Clinical Pharmacology

published in

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17 April 2018

volume

46

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17 April 2018

issue

12

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17 April 2018

page(s)

1426-1438

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17 April 2018

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Examination of 209 drugs for inhibition of cytochrome P450 2C8

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

The role of CYP2B6 in human xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Interpatient variability in the pharmacokinetics of the HIV non-nucleoside reverse transcriptase inhibitor efavirenz: the effect of gender, race, and CYP2B6 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Efavirenz and CYP2B6 polymorphism: implications for drug toxicity and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Validated assays for human cytochrome P450 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Quantitative structure-activity relationships (QSARs) for substrates of human cytochromes P450 CYP2 family enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270006293753

21 January 2018

Identifiers

DOI

10.1177/0091270006293753

1 reference

17 April 2018

1 reference

17 April 2018