(Q51935466)

English

Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease.

scientific article published on 12 August 2006

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scholarly article

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease. (English)

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

object named as

Nick Holford

4

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author name string

Peter Lockwood

1

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

Wayne Ewy

2

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

David Hermann

3

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

publication date

12 August 2006

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

Pharmaceutical Research

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

23

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

9

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Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

2050-2059

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9048-8

21 January 2018

A new rating scale for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9048-8

21 January 2018

A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9048-8

21 January 2018

A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9048-8

21 January 2018

Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9048-8

21 January 2018

A 1-year controlled trial of acetyl-l-carnitine in early-onset AD.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9048-8

21 January 2018

Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

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Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

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A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Developments of a water-maze procedure for studying spatial learning in the rat

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https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Randomized, placebo-controlled, parallel group versus crossover study designs for the study of dementia in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Drug treatment effects on disease progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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The importance of modeling interoccasion variability in population pharmacokinetic analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Alzheimer's disease: a central role for amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Clinical research designs for emerging treatments for Alzheimer disease: moving beyond placebo-controlled trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Cognition, function, and caregiving time patterns in patients with mild-to-moderate Alzheimer disease: a 12-month analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

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Simulation of clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Efficacy of xanomeline in Alzheimer disease: cognitive improvement measured using the Computerized Neuropsychological Test Battery (CNTB).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placebos in clinical trials in Alzheimer disease: an international discussion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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The effects of donepezil in Alzheimer's disease - results from a multinational trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Clinical trial simulation in drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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inferred from PubMed ID database lookup

Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Learning versus confirming in clinical drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16906456

12 December 2020

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Identifiers

10.1007/S11095-006-9048-8

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

1 reference

Europe PubMed Central

17 April 2018

http://europepmc.org/abstract/MED/16906456

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