(Q51944517)

18 April 2018

title

Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease. (English)

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18 April 2018

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Amy M Todd

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18 April 2018

Brian E Staveley

series ordinal

2

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18 April 2018

publication date

1 December 2008

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18 April 2018

published in

Genome

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18 April 2018

volume

51

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18 April 2018

issue

12

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18 April 2018

page(s)

1040-1046

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18 April 2018

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

cites work

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Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

21 January 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

1 reference

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

21 January 2018

1 reference

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

1 reference

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

21 January 2018

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A Drosophila model of Parkinson's disease

21 January 2018

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

21 January 2018

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Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.

21 January 2018

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Update on the genetics of Parkinson's disease

21 January 2018

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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

21 January 2018

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Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

21 January 2018

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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

21 January 2018

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

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Mice lacking alpha-synuclein are resistant to mitochondrial toxins

21 January 2018

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Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster

21 January 2018

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Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

21 January 2018

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Pathophysiology of synuclein aggregation in Lewy body disease.

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

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The PINK1/Parkin pathway regulates mitochondrial morphology

21 January 2018

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

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A Drosophila complementary DNA resource

21 January 2018

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

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PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.

21 January 2018

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Drosophila models pioneer a new approach to drug discovery for Parkinson's disease

21 January 2018

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

21 January 2018

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/G08-085

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18 April 2018

PubMed ID

19088817

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18 April 2018