(Q51989224)

19 April 2018

title

Immunosenescence: immune deficits in the elderly and therapeutic strategies to enhance immune competence. (English)

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19 April 2018

author name string

Frances T Hakim

series ordinal

1

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19 April 2018

Ronald E Gress

series ordinal

2

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19 April 2018

publication date

1 September 2005

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19 April 2018

Expert Review of Clinical Immunology

published in

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19 April 2018

volume

1

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19 April 2018

issue

3

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19 April 2018

page(s)

443-458

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19 April 2018

Pneumonia in the very old

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Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

21 January 2018

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Thymic epithelial cells in age-dependent involution

21 January 2018

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Essential Microenvironment for Thymopoiesis is Preserved in Human Adult and Aged Thymus

21 January 2018

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High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection.

21 January 2018

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

21 January 2018

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Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

21 January 2018

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Thymic T cell development and progenitor localization depend on CCR7.

21 January 2018

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IL-7 gene therapy in aging restores early thymopoiesis without reversing involution

21 January 2018

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In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

21 January 2018

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

21 January 2018

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Thymic generation and regeneration

21 January 2018

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Regulation of thymic epithelium by keratinocyte growth factor

21 January 2018

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Identification of a human recent thymic emigrant phenotype

21 January 2018

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Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood

21 January 2018

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HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation.

21 January 2018

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Generation of functional thymocytes in the human adult.

21 January 2018

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Effects of castration on the lymphocytes of the thymus, spleen and lymph nodes.

21 January 2018

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In vivo modulation of the distribution of thymocyte subsets by female sex steroid hormones

21 January 2018

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Effects of androgens on T and B lymphocyte development.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation

21 January 2018

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The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

21 January 2018

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

21 January 2018

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Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

21 January 2018

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Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus

21 January 2018

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21 January 2018

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Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients

21 January 2018

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T-cell generation by lymph node resident progenitor cells.

21 January 2018

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Changes in the lymph node microenvironment induced by oncostatin M.

21 January 2018

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Do thymically and strictly extrathymically developing T cells generate similar immune responses?

21 January 2018

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Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro

21 January 2018

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Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Insulin-like growth factor-1 stimulation of lymphopoiesis

21 January 2018

1 reference

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Growth hormone in T-lymphocyte thymic and postthymic development: a study in HIV-infected children

21 January 2018

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Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone.

21 January 2018

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Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice

21 January 2018

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Reversal of ageing changes in the thymus of rats by chemical or surgical castration

21 January 2018

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Aromatase inhibitors regenerate the thymus in aging male rats

21 January 2018

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Strategies to enhance T-cell reconstitution in immunocompromised patients

21 January 2018

1 reference

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Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors.

21 January 2018

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IL-7 and IL-15: therapeutic cytokines for immunodeficiency

21 January 2018

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

21 January 2018

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The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

21 January 2018

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Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation

21 January 2018

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Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function.

21 January 2018

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A dose effect of IL-7 on thymocyte development

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys

21 January 2018

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Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count

21 January 2018

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A potential role for interleukin-7 in T-cell homeostasis

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Regulation of mature T cell homeostasis

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Interleukin 7 regulates the survival and generation of memory CD4 cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Interleukin-7 restores immunity in athymic T-cell-depleted hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

A role for thymic stromal lymphopoietin in CD4(+) T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Cytokine control of memory T-cell development and survival

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

IL-15 in the life and death of lymphocytes: immunotherapeutic implications

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Interleukin-15 as an Immune Adjuvant To Increase the Efficacy of Mycobacterium bovis Bacillus Calmette-Guérin Vaccination

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

Changes in thymic function with age and during the treatment of HIV infection

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.1.3.443

21 January 2018

Identifiers

DOI

10.1586/1744666X.1.3.443

1 reference

19 April 2018

1 reference

19 April 2018