(Q52015874)

19 April 2018

title

Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. (English)

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19 April 2018

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4

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19 April 2018

Klaus Rajewsky

5

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19 April 2018

author name string

Goossens T

1

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19 April 2018

Bräuninger A

2

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19 April 2018

Klein U

3

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19 April 2018

language of work or name

English

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publication date

1 December 2001

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19 April 2018

European Journal of Immunology

published in

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19 April 2018

volume

31

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19 April 2018

issue

12

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19 April 2018

page(s)

3638-3648

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19 April 2018

Clonal selection and learning in the antibody system

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Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells

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Normal human B cells display ordered light chain gene rearrangements and deletions

21 January 2018

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Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

21 January 2018

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Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

21 January 2018

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Receptor editing: an approach by autoreactive B cells to escape tolerance

21 January 2018

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Receptor editing in self-reactive bone marrow B cells

21 January 2018

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Rearrangement of lambda light chain genes in mature B cells in vitro and in vivo. Function of reexpressed recombination-activating gene (RAG) products

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Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice

21 January 2018

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Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production

21 January 2018

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Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells

21 January 2018

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kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire

21 January 2018

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Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire.

21 January 2018

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Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes

21 January 2018

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Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes

21 January 2018

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Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells

21 January 2018

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The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression

21 January 2018

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Whole genome amplification from a single cell: implications for genetic analysis

21 January 2018

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Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor

21 January 2018

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V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

21 January 2018

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PCR amplification of murine immunoglobulin germline V genes: strategies for minimization of recombination artefacts

21 January 2018

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Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.

21 January 2018

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Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

21 January 2018

1 reference

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Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

21 January 2018

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V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

21 January 2018

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Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

21 January 2018

1 reference

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Editing disease-associated autoantibodies

21 January 2018

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The germinal center reaction

21 January 2018

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V(D)J recombinase activity in a subset of germinal center B lymphocytes

21 January 2018

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RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

21 January 2018

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Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts

21 January 2018

1 reference

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Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

21 January 2018

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Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes

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Circulating human B cells that express surrogate light chains and edited receptors

21 January 2018

1 reference

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Magnetofluorescent liposomes for increased sensitivity of immunofluorescence

21 January 2018

1 reference

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10.1002/1521-4141(200112)31:12<3638::AID-IMMU3638>3.0.CO;2-G

21 January 2018

Identifiers

DOI

1 reference

19 April 2018

PubMed ID

11745384

1 reference

19 April 2018