(Q52149452)

English

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.

scientific article published on 11 September 2015

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scholarly article

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease. (English)

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

author name string

Mari Suzuki

1

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Nobuhiro Fujikake

2

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Toshihide Takeuchi

3

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Ayako Kohyama-Koganeya

4

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Kazuki Nakajima

5

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Yoshio Hirabayashi

6

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Keiji Wada

7

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Yoshitaka Nagai

8

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

publication date

11 September 2015

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

Human Molecular Genetics

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

24

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

23

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

6675-6686

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Advances in the genetics of Parkinson disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

The risk of Parkinson's disease in type 1 Gaucher disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Lysosomal degradation of alpha-synuclein in vivo.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Structural and functional characterization of two alpha-synuclein strains

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Distinct α-synuclein strains differentially promote tau inclusions in neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Biochemical characterization of the core structure of alpha-synuclein filaments

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Neuronal and glial accumulation of alpha- and beta-synucleins in human lipidoses

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Mechanisms of neurodegeneration in mucopolysaccharidoses II and IIIB: analysis of human brain tissue

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Direct observation of the interconversion of normal and toxic forms of α-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Loss of β-glucocerebrosidase activity does not affect alpha-synuclein levels or lysosomal function in neuronal cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Acid β-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α-synuclein processing.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

GM1 specifically interacts with alpha-synuclein and inhibits fibrillation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Accumulation of glucosylceramide and glucosylsphingosine (psychosine) in cerebrum and cerebellum in infantile and juvenile Gaucher disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Brain glucocerebrosidase in Gaucher's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Glucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Unfolded protein response in Gaucher disease: from human to Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Expression of human Gaucher disease gene GBA generates neurodevelopmental defects and ER stress in Drosophila eye

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Improved immunodetection of endogenous α-synuclein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV372

21 January 2018

Identifiers

10.1093/HMG/DDV372

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

1 reference

Europe PubMed Central

23 April 2018

http://europepmc.org/abstract/MED/26362253

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