(Q52149898)

23 April 2018

title

A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis. (English)

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23 April 2018

1 reference

Gerald A Higgins

1

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23 April 2018

Ari Allyn-Feuer

series ordinal

2

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23 April 2018

Edward Barbour

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3

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23 April 2018

Brian D Athey

series ordinal

4

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23 April 2018

publication date

7 September 2015

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23 April 2018

published in

Pharmacogenomics

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23 April 2018

volume

16

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23 April 2018

issue

14

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23 April 2018

page(s)

1547-1563

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23 April 2018

Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative

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Integrative analysis of 111 reference human epigenomes

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Integrative analysis of haplotype-resolved epigenomes across human tissues.

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A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

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Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data

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Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS.

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Selecting causal genes from genome-wide association studies via functionally coherent subnetworks

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Leveraging models of cell regulation and GWAS data in integrative network-based association studies

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Joint GWAS Analysis: Comparing similar GWAS at different genomic resolutions identifies novel pathway associations with six complex diseases

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Insights from genome-wide association studies of drug response

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Defining functional DNA elements in the human genome

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21 January 2018

Omics and drug response

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Systematic localization of common disease-associated variation in regulatory DNA

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

A role for noncoding variation in schizophrenia

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Genome-wide analysis of noncoding regulatory mutations in cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Genetic and epigenetic fine mapping of causal autoimmune disease variants

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Epigenetic transgenerational inheritance of altered stress responses

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Paternal transmission of stress-induced pathologies.

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Do abused children become abusive parents?

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Epigenetics as a unifying principle in the aetiology of complex traits and diseases.

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Epigenetic inheritance and the missing heritability problem

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Epigenetics of major psychosis: progress, problems and perspectives

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Mapping the epigenetic basis of complex traits.

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Epigenetic resolution of the 'curse of complexity' in adaptive evolution of complex traits

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Long-range control of gene expression: emerging mechanisms and disruption in disease

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Variegated gene expression caused by cell-specific long-range DNA interactions

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Transcription in the context of the 3D nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Discovery and characterization of chromatin states for systematic annotation of the human genome

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

ChromHMM: automating chromatin-state discovery and characterization

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Discovery and annotation of functional chromatin signatures in the human genome

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Differential DNase I hypersensitivity reveals factor-dependent chromatin dynamics

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

DNA methylation contributes to natural human variation

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

Extensive sequence-influenced DNA methylation polymorphism in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Extensive variation in chromatin states across humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Allelic skewing of DNA methylation is widespread across the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Identification of genetic variants that affect histone modifications in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Identifying multiple causative genes at a single GWAS locus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Beyond GWASs: illuminating the dark road from association to function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Linking disease associations with regulatory information in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

PubMed and beyond: a survey of web tools for searching biomedical literature

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Annotation of functional variation in personal genomes using RegulomeDB

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Improved imputation of common and uncommon SNPs with a new reference set.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Causal analysis approaches in Ingenuity Pathway Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Pathway Commons, a web resource for biological pathway data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Influence of an interaction between lithium salts and a functional polymorphism in SLC1A2 on the history of illness in bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Response to lithium in bipolar disorder: clinical and genetic findings

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta -50 T/C SNP.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

A genome-wide association study of sleep habits and insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Association at SYNE1 in both bipolar disorder and recurrent major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Genome-wide association study identifies five new schizophrenia loci

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Association of common genetic variants of HOMER1 gene with levodopa adverse effects in Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Multiple lithium-dependent Brugada syndrome unmasking events in a bipolar patient

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Unmasking of brugada syndrome by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Replication of Genome-Wide Association Studies (GWAS) loci for sleep in the British G1219 cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.15.106

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

The functional neuroanatomy of bipolar disorder: a consensus model

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

The Human Epigenome Browser at Washington University

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Genetic and functional analysis of the DLG4 gene encoding the post-synaptic density protein 95 in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

AmiGO: online access to ontology and annotation data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Lithium: the pharmacodynamic actions of the amazing ion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Molecular actions and clinical pharmacogenetics of lithium therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Potential mechanisms of action of lithium in bipolar disorder. Current understanding

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Replication of GWAS of bipolar disorder: association of SNPs near CDH7 with bipolar disorder and visual processing

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

Evidence for association of anACCN1gene variant with response to lithium treatment in Sardinian patients with bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.15.106

21 January 2018

Identifiers

DOI

10.2217/PGS.15.106

1 reference

23 April 2018

PubMed ID

26343379

1 reference

23 April 2018