(Q52152185)

23 April 2018

title

Astrocytes promote glioma invasion via the gap junction protein connexin43. (English)

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23 April 2018

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W C Sin

1

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23 April 2018

Q Aftab

2

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23 April 2018

J F Bechberger

3

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23 April 2018

J H Leung

4

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23 April 2018

H Chen

5

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23 April 2018

C C Naus

6

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23 April 2018

language of work or name

English

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publication date

13 July 2015

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23 April 2018

published in

Oncogene

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23 April 2018

volume

35

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23 April 2018

issue

12

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23 April 2018

page(s)

1504-1516

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23 April 2018

https://scigraph.springernature.com/pub.10.1038/onc.2015.210

exact match

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21 January 2018

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Mutation of a conserved threonine in the third transmembrane helix of alpha- and beta-connexins creates a dominant-negative closed gap junction channel

21 January 2018

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Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity

21 January 2018

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Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43.

21 January 2018

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Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment.

21 January 2018

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Biochemical and immunocytochemical changes in glial fibrillary acidic protein after stab wounds.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Astrocytes enhance the invasion potential of glioblastoma stem-like cells

21 January 2018

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Calcium waves between astrocytes from Cx43 knockout mice

21 January 2018

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Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Gene expression alterations in connexin null mice extend beyond the gap junction.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Array analysis of gene expression in connexin-43 null astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.210

Mice with astrocyte‐directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.210

Connexin 43 regulates astrocytic migration and proliferation in response to injury.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Astrocyte cultures from conditional connexin43-deficient mice.

21 January 2018

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Involvement of the cytoplasmic C-terminal domain of connexin43 in neuronal migration.

21 January 2018

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Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes

21 January 2018

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Gap junction proteins on the move: connexins, the cytoskeleton and migration

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Purines, purinergic receptors, and cancer

21 January 2018

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Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress

21 January 2018

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Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures.

21 January 2018

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Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels

21 January 2018

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Connexins regulate calcium signaling by controlling ATP release

21 January 2018

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Connexin phosphorylation as a regulatory event linked to channel gating

21 January 2018

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C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques

21 January 2018

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Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Astrocyte reactivity and reactive astrogliosis: costs and benefits

21 January 2018

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Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Connexin channel-dependent signaling pathways in inflammation.

21 January 2018

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β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Standard of care therapy for malignant glioma and its effect on tumor and stromal cells

21 January 2018

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Microenvironmental regulation of metastasis

21 January 2018

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Microenvironmental regulation of cancer development

21 January 2018

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The use of connexin-based therapeutic approaches to target inflammatory diseases.

21 January 2018

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Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape

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Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments

21 January 2018

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Connexin-based channels in astrocytes: how to study their properties.

21 January 2018

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Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.210

Ischemia-induced cellular redistribution of the astrocytic gap junctional protein connexin43 in rat brain

21 January 2018

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Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator-plasmin cascade.

21 January 2018

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Functional hemichannels in astrocytes: a novel mechanism of glutamate release.

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Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells.

31 March 2020

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Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury

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Astrocytic gap junction removal, connexin43 redistribution, and epitope masking at excitatory amino acid lesion sites in rat brain

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Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43.

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Connexin43 null mice reveal that astrocytes express multiple connexins

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Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin43

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Hemichannels in cardiomyocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia

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CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.

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GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS

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Intercellular communication in spinal cord astrocytes: fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation

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Identifiers

DOI

10.1038/ONC.2015.210

1 reference

23 April 2018

PubMed ID

26165844

1 reference

23 April 2018