(Q52207066)

27 April 2018

title

Generation and characterization of a delta F508 cystic fibrosis mouse model. (English)

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27 April 2018

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2

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27 April 2018

author name string

Colledge WH

1

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27 April 2018

Southern KW

3

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27 April 2018

Ratcliff R

4

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27 April 2018

Jiang C

5

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27 April 2018

Cheng SH

6

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27 April 2018

MacVinish LJ

7

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27 April 2018

Anderson JR

8

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27 April 2018

Cuthbert AW

9

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27 April 2018

Evans MJ

10

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27 April 2018

language of work or name

English

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publication date

1 August 1995

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27 April 2018

published in

Nature Genetics

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27 April 2018

volume

10

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27 April 2018

page(s)

445-452

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27 April 2018

issue

4

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27 April 2018

https://scigraph.springernature.com/pub.10.1038/ng0895-445

exact match

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cites work

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Cystic fibrosis in the mouse by targeted insertional mutagenesis

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Production of a severe cystic fibrosis mutation in mice by gene targeting

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Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans

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Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

21 January 2018

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

21 January 2018

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The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR.

21 January 2018

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A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

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The genetic advantage hypothesis in cystic fibrosis heterozygotes: a murine study

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Developmental differences of cystic fibrosis transmembrane conductance regulator functional expression in isolated rat fetal distal airway epithelial cells.

21 January 2018

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Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

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Identification of the cystic fibrosis gene: genetic analysis

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Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

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An animal model for cystic fibrosis made by gene targeting

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Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis

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A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.

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CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse

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Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

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Differential acidic pH sensitivity of delta F508 CFTR Cl- channel activity in lipid bilayers.

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7 January 2021

Effects of the delta F508 mutation on the structure, function, and folding of the first nucleotide-binding domain of CFTR.

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The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment

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Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis

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Anomalies in ion transport in CF mouse tracheal epithelium

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Abnormal Ion Permeation Through Cystic Fibrosis Respiratory Epithelium

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7 January 2021

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

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7 January 2021

Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manif

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7 January 2021

Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression.

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7 January 2021

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells

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7 January 2021

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

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7 January 2021

Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/NG0895-445

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27 April 2018

PubMed ID

7545494

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27 April 2018