(Q52231893)

27 April 2018

title

Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. (English)

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27 April 2018

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Hicks KO

1

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27 April 2018

Fleming Y

2

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27 April 2018

Siim BG

3

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27 April 2018

Koch CJ

4

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27 April 2018

Wilson WR

5

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27 April 2018

language of work or name

English

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publication date

1 October 1998

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27 April 2018

International Journal of Radiation Oncology Biology Physics

published in

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27 April 2018

volume

42

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27 April 2018

issue

3

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27 April 2018

page(s)

641-649

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27 April 2018

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

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Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

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SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

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Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine

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Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice

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Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine

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Evaluation of bioreductive drugs in multicell spheroids

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An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours

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Multilayers of cells growing on a permeable support. An in vitro tumour model

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Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity

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7 January 2021

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

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7 January 2021

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro

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7 January 2021

Effect of intravenous drug administration mode on drug distribution in a tumor slab: a finite Fourier transform analysis

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7 January 2021

Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid

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7 January 2021

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Identifiers

DOI

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27 April 2018

PubMed ID

9806526

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27 April 2018