(Q36080580)

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Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

0 references

author name string

P L Olive

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

0 references

publication date

1 March 1995

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

71

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

529-536

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

https://scigraph.springernature.com/pub.10.1038/bjc.1995.105

0 references

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: influence of growth kinetics, growth environment and DNA packaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Intermittent blood flow in a murine tumor: radiobiological effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Bioreductive drugs and the selective induction of tumour hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Factors influencing DNA migration from individual cells subjected to gel electrophoresis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Definitive evidence for hypoxic cells influencing cure in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

2 October 2017

Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and 125IdUrd

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

11 July 2018

Studies on the Radiosensitizing Effect of Oxygen in Chinese Hamster Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

11 July 2018

Pre- and post-irradiation radiosensitization by SR 4233.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

11 July 2018

Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

11 July 2018

Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

11 July 2018

Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

23 September 2018

Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

23 September 2018

Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033654

23 September 2018

Radiation-induced reoxygenation in the SCCVII murine tumour: evidence for a decrease in oxygen consumption and an increase in tumour perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms for the hypoxia-dependent activation of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution, oxygenation, and clonogenicity of macrophages in a murine tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA double-strand breaks measured in individual cells subjected to gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of bioreductive drugs in multicell spheroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second-generation 1,2,4-benzotriazine 1,4-di-N-oxide bioreductive anti-tumor agents: pharmacology and activity in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of hypoxic cells in a murine tumor with the use of the comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxic fractions measured in murine tumors and normal tissues using the comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.1995.105

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

0 references

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